biostudies-literatureBennington JNIH HHS646087https://www.ebi.ac.uk/biostudies/studies/S-EPMC7969654biostudies-literatureUnknown8<b>Background:</b> Chronic tubulointerstitial fibrosis is a common final pathway leading to end stage kidney disease in cats and has no effective treatment. The use of cell-based molecules to treat kidney fibrosis may be a promising approach. The objectives were to test the effects of intra-renal chemokine CXCL12 injection in a pre-clinical cat model of unilateral ischemia/reperfusion (I/R)-induced kidney fibrosis and then, within a clinical pilot study, test the safety/feasibility of CXCL12 injection in cats that might have early chronic kidney disease (CKD). <b>Methods:</b> <i>Pre-clinical</i>: Thirty cats received intra-renal injection of 100, 200, or 400 ng of recombinant human CXCL12, or sterile saline, into the I/R kidney 70 days post-injury, or were non-injured, non-injected controlFrontiers in veterinary scienceChemokine Therapy in Cats With Experimental Renal Fibrosis and in a Kidney Disease Pilot Study.PMC7969654T32 OD010957Shankle DSuparto ILankford SFanning JBadlani GMariya SPutra MAKusumawardhani WKartini CBennington JMagalhaes RSWilliams JKfalseChemokine Therapy in Cats With Experimental Renal Fibrosis and in a Kidney Disease Pilot Study.<b>Background:</b> Chronic tubulointerstitial fibrosis is a common final pathway leading to end stage kidney disease in cats and has no effective treatment. The use of cell-based molecules to treat kidney fibrosis may be a promising approach. The objectives were to test the effects of intra-renal chemokine CXCL12 injection in a pre-clinical cat model of unilateral ischemia/reperfusion (I/R)-induced kidney fibrosis and then, within a clinical pilot study, test the safety/feasibility of CXCL12 injection in cats that might have early chronic kidney disease (CKD). <b>Methods:</b> <i>Pre-clinical</i>: Thirty cats received intra-renal injection of 100, 200, or 400 ng of recombinant human CXCL12, or sterile saline, into the I/R kidney 70 days post-injury, or were non-injured, non-injected control2021-01-01T00:00:00Z20212026-06-19T03:11:29.907Z2024-11-21T04:51:05.136ZS-EPMC79696543374821910.3389/fvets.2021.646087