{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee SS"],"funding":["National Health and Medical Research Council"],"pagination":["6147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7969753"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein (CRP) level trajectory and pack-years smoked. Participants from the Raine study, a longitudinal cohort study, had serum CRP levels analysed at the 14-, 17-, and 20-year follow-ups. Group-based trajectory modelling was used to classify participants according to their 7-year CRP levels. At the 20-year follow-up (at 18-22 years old), participants completed questionnaires on their smoking history, and underwent optical coherence tomography imaging to obtain their choroidal and retinal thicknesses at the macula. Three CRP trajectories were identified: consistently low CRP levels (78% of sa"],"journal":["Scientific reports"],"pubmed_title":["Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults."],"pmcid":["PMC7969753"],"funding_grant_id":["Medical Research Future Fund Career Development Fellowship","1021105","Early Career Fellowship"],"pubmed_authors":["Mackey DA","Yazar S","Lee SS","Chen FK","Beales DJ","Alonso-Caneiro D"],"additional_accession":[]},"is_claimable":false,"name":"Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults.","description":"Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein (CRP) level trajectory and pack-years smoked. Participants from the Raine study, a longitudinal cohort study, had serum CRP levels analysed at the 14-, 17-, and 20-year follow-ups. Group-based trajectory modelling was used to classify participants according to their 7-year CRP levels. At the 20-year follow-up (at 18-22 years old), participants completed questionnaires on their smoking history, and underwent optical coherence tomography imaging to obtain their choroidal and retinal thicknesses at the macula. Three CRP trajectories were identified: consistently low CRP levels (78% of sa","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-19T15:37:46.946Z","creation":"2025-04-19T15:37:46.946Z"},"accession":"S-EPMC7969753","cross_references":{"pubmed":["33731739"],"doi":["10.1038/s41598-021-85626-3"]}}