biostudies-literatureLee SSNational Health and Medical Research Council6147https://www.ebi.ac.uk/biostudies/studies/S-EPMC7969753biostudies-literatureUnknown11(1)Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein (CRP) level trajectory and pack-years smoked. Participants from the Raine study, a longitudinal cohort study, had serum CRP levels analysed at the 14-, 17-, and 20-year follow-ups. Group-based trajectory modelling was used to classify participants according to their 7-year CRP levels. At the 20-year follow-up (at 18-22 years old), participants completed questionnaires on their smoking history, and underwent optical coherence tomography imaging to obtain their choroidal and retinal thicknesses at the macula. Three CRP trajectories were identified: consistently low CRP levels (78% of saScientific reportsAssociations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults.PMC7969753Medical Research Future Fund Career Development Fellowship1021105Early Career FellowshipMackey DAYazar SLee SSChen FKBeales DJAlonso-Caneiro DfalseAssociations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults.Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein (CRP) level trajectory and pack-years smoked. Participants from the Raine study, a longitudinal cohort study, had serum CRP levels analysed at the 14-, 17-, and 20-year follow-ups. Group-based trajectory modelling was used to classify participants according to their 7-year CRP levels. At the 20-year follow-up (at 18-22 years old), participants completed questionnaires on their smoking history, and underwent optical coherence tomography imaging to obtain their choroidal and retinal thicknesses at the macula. Three CRP trajectories were identified: consistently low CRP levels (78% of sa2021-01-01T00:00:00Z2021 Mar2025-04-19T15:37:46.946Z2025-04-19T15:37:46.946ZS-EPMC79697533373173910.1038/s41598-021-85626-3