{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["95"],"submitter":["Delshad M"],"funding":["Shahid Beheshti University of Medical Sciences"],"pubmed_abstract":["The incidence of the novel coronavirus disease (COVID-19) outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought daunting complications for people as well as physicians around the world. An ever-increasing number of studies investigating the characteristics of the disease, day by day, is shedding light on a new feature of the virus with the hope that eventually these efforts lead to the proper treatment. SARS-CoV-2 activates antiviral immune responses, but in addition may overproduce pro-inflammatory cytokines, causing uncontrolled inflammatory responses in patients with severe COVID-19. This condition may lead to lymphopenia and lymphocyte dysfunction, which in turn, predispose patients to further infections, septic shock, and severe multiple organ"],"journal":["International immunopharmacology"],"pagination":["107586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7969831"],"repository":["biostudies-literature"],"pubmed_title":["The contributory role of lymphocyte subsets, pathophysiology of lymphopenia and its implication as prognostic and therapeutic opportunity in COVID-19."],"pmcid":["PMC7969831"],"pubmed_authors":["Bashash D","Pourbagheri-Sigaroodi A","Delshad M","Tavakolinia N","Safaroghli-Azar A","Bagheri N"],"additional_accession":[]},"is_claimable":false,"name":"The contributory role of lymphocyte subsets, pathophysiology of lymphopenia and its implication as prognostic and therapeutic opportunity in COVID-19.","description":"The incidence of the novel coronavirus disease (COVID-19) outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought daunting complications for people as well as physicians around the world. An ever-increasing number of studies investigating the characteristics of the disease, day by day, is shedding light on a new feature of the virus with the hope that eventually these efforts lead to the proper treatment. SARS-CoV-2 activates antiviral immune responses, but in addition may overproduce pro-inflammatory cytokines, causing uncontrolled inflammatory responses in patients with severe COVID-19. This condition may lead to lymphopenia and lymphocyte dysfunction, which in turn, predispose patients to further infections, septic shock, and severe multiple organ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-19T17:59:32.265Z","creation":"2022-02-11T14:15:15.095Z"},"accession":"S-EPMC7969831","cross_references":{"pubmed":["33765611"],"doi":["10.1016/j.intimp.2021.107586"]}}