{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Hoshino K"],"pubmed_abstract":["<b>Introduction:</b> Post-synaptic dopamine receptor supersensitivity (DARSS) has been extensively researched by Dr. Masaya Segawa, who has investigated the efficacy of very-low-dose levodopa therapy (VLDT; 0.5-1 mg/kg/day). Considerable Japanese research supports the possibility that VLDT could be used to treat pediatric neurological disorders. We conducted an on-line survey in 2014 to collect real-world data on the use of VLDT to treat DARSS. <b>Methods:</b> A two-step survey, including a screening test and questionnaire, was posted on a private internet site that could be accessed via the VLDT Research Group home page, and 1,165 pediatric neurologists across Japan were invited to complete it. <b>Results:</b> A total of 25 respondents reported prescribing VLDT; 19 used VLDT to treat auti"],"journal":["Frontiers in pediatrics"],"pagination":["569594"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7970027"],"repository":["biostudies-literature"],"pubmed_title":["Very-Low-Dose Levodopa Therapy for Pediatric Neurological Disorders: A Preliminary Questionnaire in Japan."],"pmcid":["PMC7970027"],"pubmed_authors":["Nezu A","Hoshino K","Yasuhara A","Kimura K","Hayashi M","Ishizaki A","Kubota M"],"additional_accession":[]},"is_claimable":false,"name":"Very-Low-Dose Levodopa Therapy for Pediatric Neurological Disorders: A Preliminary Questionnaire in Japan.","description":"<b>Introduction:</b> Post-synaptic dopamine receptor supersensitivity (DARSS) has been extensively researched by Dr. Masaya Segawa, who has investigated the efficacy of very-low-dose levodopa therapy (VLDT; 0.5-1 mg/kg/day). Considerable Japanese research supports the possibility that VLDT could be used to treat pediatric neurological disorders. We conducted an on-line survey in 2014 to collect real-world data on the use of VLDT to treat DARSS. <b>Methods:</b> A two-step survey, including a screening test and questionnaire, was posted on a private internet site that could be accessed via the VLDT Research Group home page, and 1,165 pediatric neurologists across Japan were invited to complete it. <b>Results:</b> A total of 25 respondents reported prescribing VLDT; 19 used VLDT to treat auti","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T22:01:01.4Z","creation":"2025-04-04T22:01:01.4Z"},"accession":"S-EPMC7970027","cross_references":{"pubmed":["33748036"],"doi":["10.3389/fped.2021.569594"]}}