{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["MacArthur TA"],"funding":["NCATS NIH HHS","NCRR NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["321-325"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7970628"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(3)"],"pubmed_abstract":["Introduction
We hypothesize that a patient (pt) with accelerated thrombin generation, time to peak height (ttPeak), will have a greater odds of meeting critical administration threshold (CAT) criteria (> 3 packed red blood cell [pRBC] transfusions [Tx] per 60 min interval), within the first 24 h after injury, independent of international normalized ratio (INR).Methods
In a prospective cohort study, trauma patients were enrolled over a 4.5-year period and serial blood samples collected at various time points. We retrospectively stratified pts into three categories: CAT+, CAT- but receiving some pRBC Tx, receiving no Tx within the first 24 h. Blood collected prior to Tx was analyzed for thrombin generation parameters and prothrombin time (PT)/INR.Results
A total of 48"],"journal":["Shock (Augusta, Ga.)"],"pubmed_title":["Thrombin Generation Kinetics are Predictive of Rapid Transfusion in Trauma Patients Meeting Critical Administration Threshold."],"pmcid":["PMC7970628"],"funding_grant_id":["UM1 HL120877","R01 GM126086","UL1 TR000135","R01 HL066216","K08 GM093133","UL1 RR024150"],"pubmed_authors":["Halling TM","Spears GM","Bailey KR","Ferrara MJ","Dong JF","Jenkins DH","Ashrani AA","Immermann JM","Park MS","Kozar RA","Auton M","MacArthur TA"],"additional_accession":[]},"is_claimable":false,"name":"Thrombin Generation Kinetics are Predictive of Rapid Transfusion in Trauma Patients Meeting Critical Administration Threshold.","description":"Introduction
We hypothesize that a patient (pt) with accelerated thrombin generation, time to peak height (ttPeak), will have a greater odds of meeting critical administration threshold (CAT) criteria (> 3 packed red blood cell [pRBC] transfusions [Tx] per 60 min interval), within the first 24 h after injury, independent of international normalized ratio (INR).Methods
In a prospective cohort study, trauma patients were enrolled over a 4.5-year period and serial blood samples collected at various time points. We retrospectively stratified pts into three categories: CAT+, CAT- but receiving some pRBC Tx, receiving no Tx within the first 24 h. Blood collected prior to Tx was analyzed for thrombin generation parameters and prothrombin time (PT)/INR.Results
A total of 48","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T19:54:30.68Z","creation":"2025-04-04T19:54:30.68Z"},"accession":"S-EPMC7970628","cross_references":{"pubmed":["32826809"],"doi":["10.1097/SHK.0000000000001633","10.1097/shk.0000000000001633"]}}