biostudies-literatureMacArthur TANCATS NIH HHSNCRR NIH HHSNHLBI NIH HHSNIGMS NIH HHS321-325https://www.ebi.ac.uk/biostudies/studies/S-EPMC7970628biostudies-literatureUnknown55(3)<h4>Introduction</h4>We hypothesize that a patient (pt) with accelerated thrombin generation, time to peak height (ttPeak), will have a greater odds of meeting critical administration threshold (CAT) criteria (> 3 packed red blood cell [pRBC] transfusions [Tx] per 60 min interval), within the first 24 h after injury, independent of international normalized ratio (INR).<h4>Methods</h4>In a prospective cohort study, trauma patients were enrolled over a 4.5-year period and serial blood samples collected at various time points. We retrospectively stratified pts into three categories: CAT+, CAT- but receiving some pRBC Tx, receiving no Tx within the first 24 h. Blood collected prior to Tx was analyzed for thrombin generation parameters and prothrombin time (PT)/INR.<h4>Results</h4>A total of 48Shock (Augusta, Ga.)Thrombin Generation Kinetics are Predictive of Rapid Transfusion in Trauma Patients Meeting Critical Administration Threshold.PMC7970628UM1 HL120877R01 GM126086UL1 TR000135R01 HL066216K08 GM093133UL1 RR024150Halling TMSpears GMBailey KRFerrara MJDong JFJenkins DHAshrani AAImmermann JMPark MSKozar RAAuton MMacArthur TAfalseThrombin Generation Kinetics are Predictive of Rapid Transfusion in Trauma Patients Meeting Critical Administration Threshold.<h4>Introduction</h4>We hypothesize that a patient (pt) with accelerated thrombin generation, time to peak height (ttPeak), will have a greater odds of meeting critical administration threshold (CAT) criteria (> 3 packed red blood cell [pRBC] transfusions [Tx] per 60 min interval), within the first 24 h after injury, independent of international normalized ratio (INR).<h4>Methods</h4>In a prospective cohort study, trauma patients were enrolled over a 4.5-year period and serial blood samples collected at various time points. We retrospectively stratified pts into three categories: CAT+, CAT- but receiving some pRBC Tx, receiving no Tx within the first 24 h. Blood collected prior to Tx was analyzed for thrombin generation parameters and prothrombin time (PT)/INR.<h4>Results</h4>A total of 482021-01-01T00:00:00Z2021 Mar2025-04-04T19:54:30.68Z2025-04-04T19:54:30.68ZS-EPMC79706283282680910.1097/SHK.000000000000163310.1097/shk.0000000000001633