{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shimada A"],"funding":["Japan Society for the Promotion of Science"],"pagination":["520-528"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7973137"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["Sepsis-associated encephalopathy (SAE) is characterized as diffuse brain dysfunction in patients with excessive systemic inflammatory reaction to an infection. In our previous studies using a mouse model of SAE with intraperitoneal injection of lipopolysaccharide (LPS), tissue concentrations of various cytokines were elevated in the entire brain parenchyma 4 and 24 h following LPS administration. Cytokines elevated at 4 h were produced by the choroid plexus, leptomeninges and vascular endothelium, while those at 24 h were produced by astrocytes. Interleukin (IL)-1β did not increase in the concentration in the brain parenchyma during the period from 1 to 24 h following LPS. In the present study, we hypothesized that the intracranial cells that initially respond to systemic inflammation are "],"journal":["Toxicology reports"],"pubmed_title":["Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice."],"pmcid":["PMC7973137"],"funding_grant_id":["18K07072","25290020"],"pubmed_authors":["Hasegawa-Ishii S","Shimada A"],"additional_accession":[]},"is_claimable":false,"name":"Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice.","description":"Sepsis-associated encephalopathy (SAE) is characterized as diffuse brain dysfunction in patients with excessive systemic inflammatory reaction to an infection. In our previous studies using a mouse model of SAE with intraperitoneal injection of lipopolysaccharide (LPS), tissue concentrations of various cytokines were elevated in the entire brain parenchyma 4 and 24 h following LPS administration. Cytokines elevated at 4 h were produced by the choroid plexus, leptomeninges and vascular endothelium, while those at 24 h were produced by astrocytes. Interleukin (IL)-1β did not increase in the concentration in the brain parenchyma during the period from 1 to 24 h following LPS. In the present study, we hypothesized that the intracranial cells that initially respond to systemic inflammation are ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-05T13:48:43.722Z","creation":"2025-04-05T13:48:43.722Z"},"accession":"S-EPMC7973137","cross_references":{"pubmed":["33747797"],"doi":["10.1016/j.toxrep.2021.03.002"]}}