biostudies-literatureUnknown11(1)Bruells CSRWTH AachenN-acetyl-para-amino phenol (APAP, usually named paracetamol), which is commonly used for its analgesic and antipyretic properties may lead to hepatotoxicity and acute liver damage in case of overdoses. Released cytokines and oxidative stress following acute liver damage may affect other organs' function notably the diaphragm, which is particularly sensitive to oxidative stress and circulating cytokines. We addressed this issue in a mouse model of acute liver injury induced by administration of APAP. C57BL/6J mice (each n = 8) were treated with N-acetyl-para-amino phenol (APAP) to induce acute drug caused liver injury and sacrificed 12 or 24 h afterwards. An untreated group served as controls. Key markers of inflammation, proteolysis, autophagy and oxidative stress were measured in diaphragScientific reports6302https://www.ebi.ac.uk/biostudies/studies/S-EPMC7973759biostudies-literatureAcute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm.PMC7973759Marx GTacke FKrenkel OBruells CSGayan-Ramirez GFrank NDuschner PMossanen JCBreuer TfalseAcute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm.N-acetyl-para-amino phenol (APAP, usually named paracetamol), which is commonly used for its analgesic and antipyretic properties may lead to hepatotoxicity and acute liver damage in case of overdoses. Released cytokines and oxidative stress following acute liver damage may affect other organs' function notably the diaphragm, which is particularly sensitive to oxidative stress and circulating cytokines. We addressed this issue in a mouse model of acute liver injury induced by administration of APAP. C57BL/6J mice (each n = 8) were treated with N-acetyl-para-amino phenol (APAP) to induce acute drug caused liver injury and sacrificed 12 or 24 h afterwards. An untreated group served as controls. Key markers of inflammation, proteolysis, autophagy and oxidative stress were measured in diaphrag2021-01-01T00:00:00Z2021 Mar2025-04-22T17:51:04.116Z2025-04-06T02:12:46.419ZS-EPMC79737593373770210.1038/s41598-021-85859-2