biostudies-literatureAbumiya MJapan Society for the Promotion of Science6362https://www.ebi.ac.uk/biostudies/studies/S-EPMC7973796biostudies-literatureUnknown11(1)The purpose of this study was to investigate the effects of SLC22A2 808G>T polymorphism and trough concentrations (C₀) of bosutinib on serum creatinine in 28 patients taking bosutinib. At 1, 3, 6, 12, 24, and 36 months after administration, analysis of bosutinib C₀ and creatinine was performed at the same time of day. Significant correlations were observed between bosutinib C₀ and the change rate of serum creatinine or the estimated glomerular filtration rate (eGFR; r = 0.328, P < 0.001 and r = - 0.315, P < 0.001, respectively). These correlations were particularly high in patients having the SLC22A2 808G/G genotype (r = 0.345 and r = - 0.329, respectively); however, in patients having the 808T allele, there were no significant differences. In multivariate Scientific reportsEffects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy.PMC797379620K07150Takahashi SYoshioka TMiura MTakahashi NAbumiya MKameoka YfalseEffects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy.The purpose of this study was to investigate the effects of SLC22A2 808G>T polymorphism and trough concentrations (C₀) of bosutinib on serum creatinine in 28 patients taking bosutinib. At 1, 3, 6, 12, 24, and 36 months after administration, analysis of bosutinib C₀ and creatinine was performed at the same time of day. Significant correlations were observed between bosutinib C₀ and the change rate of serum creatinine or the estimated glomerular filtration rate (eGFR; r = 0.328, P < 0.001 and r = - 0.315, P < 0.001, respectively). These correlations were particularly high in patients having the SLC22A2 808G/G genotype (r = 0.345 and r = - 0.329, respectively); however, in patients having the 808T allele, there were no significant differences. In multivariate 2021-01-01T00:00:00Z2021 Mar2025-04-25T19:22:19.795Z2025-04-06T07:58:37.197ZS-EPMC79737963373761810.1038/s41598-021-85757-7