biostudies-literatureUnknown91(7-S)Giotta Lucifero A<h4>Background</h4>Immune tolerance, immune escape, neoangiogenesis, phenotypic changes, and glioma stem cells are all responsible for the resistance of malignant brain tumors to current therapies and persistent recurrence. The present study provides a panoramic view of innovative therapies for malignant brain tumors, especially glioblastoma, aimed at achieving a tailored approach.<h4>Methods</h4>PubMed/Medline and ClinicalTrials.gov were the main sources of an extensive literature review in which "Regenerative Medicine," "Cell-Based Therapy," "Chemotherapy," "Vaccine," "Cell Engineering," "Immunotherapy, Active," "Immunotherapy, Adoptive," "Stem Cells," "Gene Therapy," "Target Therapy," "Brain Cancer," "Glioblastoma," and "Malignant Brain Tumor" were the search terms. Only articles in EngActa bio-medica : Atenei Parmensis5-17https://www.ebi.ac.uk/biostudies/studies/S-EPMC7975829biostudies-literatureInnovative therapies for malignant brain tumors: the road to a tailored cure.PMC7975829Luzzi SMosconi MSavasta SGiotta Lucifero AFoiadelli TBrambilla ITrabatti CfalseInnovative therapies for malignant brain tumors: the road to a tailored cure.<h4>Background</h4>Immune tolerance, immune escape, neoangiogenesis, phenotypic changes, and glioma stem cells are all responsible for the resistance of malignant brain tumors to current therapies and persistent recurrence. The present study provides a panoramic view of innovative therapies for malignant brain tumors, especially glioblastoma, aimed at achieving a tailored approach.<h4>Methods</h4>PubMed/Medline and ClinicalTrials.gov were the main sources of an extensive literature review in which "Regenerative Medicine," "Cell-Based Therapy," "Chemotherapy," "Vaccine," "Cell Engineering," "Immunotherapy, Active," "Immunotherapy, Adoptive," "Stem Cells," "Gene Therapy," "Target Therapy," "Brain Cancer," "Glioblastoma," and "Malignant Brain Tumor" were the search terms. Only articles in Eng2020-01-01T00:00:00Z2020 Jun2025-04-04T08:27:40.182Z2025-04-04T08:27:40.182ZS-EPMC79758293260837210.23750/abm.v91i7-S.9951