{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strobbia P"],"funding":["NIBIB NIH HHS"],"pagination":["4090-4102"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7977455"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(9)"],"pubmed_abstract":["For the majority of cancer patients, surgery is the primary method of treatment. In these cases, accurately removing the entire tumor without harming surrounding tissue is critical; however, due to the lack of intraoperative imaging techniques, surgeons rely on visual and physical inspection to identify tumors. Surface-enhanced Raman scattering (SERS) is emerging as a non-invasive optical alternative for intraoperative tumor identification, with high accuracy and stability. However, Raman detection requires dark rooms to work, which is not consistent with surgical settings. <b>Methods:</b> Herein, we used SERS nanoprobes combined with shifted-excitation Raman difference spectroscopy (SERDS) detection, to accurately detect tumors in xenograft murine model. <b>Results:</b> We demonstrate for"],"journal":["Theranostics"],"pubmed_title":["Accurate <i>in vivo</i> tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS)."],"pmcid":["PMC7977455"],"funding_grant_id":["R01 EB028078"],"pubmed_authors":["Liu Y","Fales AM","Pfefer TJ","Sumpf B","Cupil-Garcia V","Crawford BM","Strobbia P","Maiwald M","Vo-Dinh T"],"additional_accession":[]},"is_claimable":false,"name":"Accurate <i>in vivo</i> tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS).","description":"For the majority of cancer patients, surgery is the primary method of treatment. In these cases, accurately removing the entire tumor without harming surrounding tissue is critical; however, due to the lack of intraoperative imaging techniques, surgeons rely on visual and physical inspection to identify tumors. Surface-enhanced Raman scattering (SERS) is emerging as a non-invasive optical alternative for intraoperative tumor identification, with high accuracy and stability. However, Raman detection requires dark rooms to work, which is not consistent with surgical settings. <b>Methods:</b> Herein, we used SERS nanoprobes combined with shifted-excitation Raman difference spectroscopy (SERDS) detection, to accurately detect tumors in xenograft murine model. <b>Results:</b> We demonstrate for","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-25T18:38:41.406Z","creation":"2025-04-06T07:41:18.14Z"},"accession":"S-EPMC7977455","cross_references":{"pubmed":["33754050"],"doi":["10.7150/thno.53101"]}}