{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(9)"],"submitter":["Wan J"],"pubmed_abstract":["<b>Rationale:</b> Prodrug strategies that render the drug temporarily inactive through a cleavable linkage are able to modulate the physicochemical properties of drugs for adaptive nanoparticle (NP) formulation. Here we used cabazitaxel as a model compound to test the validity of our \"balancing NP stability and specific drug activation\" strategy. <b>Methods:</b> Cabazitaxel is conjugated to hydrophobic polylactide fragments with varying chain lengths <i>via</i> a self-immolation linkage, yielding polymeric prodrugs that can be reactivated by reductive agents in cells. Following a nanoprecipitation protocol, cabazitaxel prodrugs can be stably entrapped in amphiphilic polyethylene-<i>block</i>-polylactide matrices to form core-shell nanotherapies with augmented colloidal stability. <b>Result"],"journal":["Theranostics"],"pagination":["4137-4154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7977460"],"repository":["biostudies-literature"],"pubmed_title":["Balancing the stability and drug activation in adaptive nanoparticles potentiates chemotherapy in multidrug-resistant cancer."],"pmcid":["PMC7977460"],"pubmed_authors":["Qi H","Wan J","Huang L","Wang H","Jin J","Cheng J"],"additional_accession":[]},"is_claimable":false,"name":"Balancing the stability and drug activation in adaptive nanoparticles potentiates chemotherapy in multidrug-resistant cancer.","description":"<b>Rationale:</b> Prodrug strategies that render the drug temporarily inactive through a cleavable linkage are able to modulate the physicochemical properties of drugs for adaptive nanoparticle (NP) formulation. Here we used cabazitaxel as a model compound to test the validity of our \"balancing NP stability and specific drug activation\" strategy. <b>Methods:</b> Cabazitaxel is conjugated to hydrophobic polylactide fragments with varying chain lengths <i>via</i> a self-immolation linkage, yielding polymeric prodrugs that can be reactivated by reductive agents in cells. Following a nanoprecipitation protocol, cabazitaxel prodrugs can be stably entrapped in amphiphilic polyethylene-<i>block</i>-polylactide matrices to form core-shell nanotherapies with augmented colloidal stability. <b>Result","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-25T18:39:12.143Z","creation":"2025-04-06T07:41:24.345Z"},"accession":"S-EPMC7977460","cross_references":{"pubmed":["33754053"],"doi":["10.7150/thno.54066"]}}