biostudies-literatureUnknown11(9)Wan J<b>Rationale:</b> Prodrug strategies that render the drug temporarily inactive through a cleavable linkage are able to modulate the physicochemical properties of drugs for adaptive nanoparticle (NP) formulation. Here we used cabazitaxel as a model compound to test the validity of our "balancing NP stability and specific drug activation" strategy. <b>Methods:</b> Cabazitaxel is conjugated to hydrophobic polylactide fragments with varying chain lengths <i>via</i> a self-immolation linkage, yielding polymeric prodrugs that can be reactivated by reductive agents in cells. Following a nanoprecipitation protocol, cabazitaxel prodrugs can be stably entrapped in amphiphilic polyethylene-<i>block</i>-polylactide matrices to form core-shell nanotherapies with augmented colloidal stability. <b>ResultTheranostics4137-4154https://www.ebi.ac.uk/biostudies/studies/S-EPMC7977460biostudies-literatureBalancing the stability and drug activation in adaptive nanoparticles potentiates chemotherapy in multidrug-resistant cancer.PMC7977460Qi HWan JHuang LWang HJin JCheng JfalseBalancing the stability and drug activation in adaptive nanoparticles potentiates chemotherapy in multidrug-resistant cancer.<b>Rationale:</b> Prodrug strategies that render the drug temporarily inactive through a cleavable linkage are able to modulate the physicochemical properties of drugs for adaptive nanoparticle (NP) formulation. Here we used cabazitaxel as a model compound to test the validity of our "balancing NP stability and specific drug activation" strategy. <b>Methods:</b> Cabazitaxel is conjugated to hydrophobic polylactide fragments with varying chain lengths <i>via</i> a self-immolation linkage, yielding polymeric prodrugs that can be reactivated by reductive agents in cells. Following a nanoprecipitation protocol, cabazitaxel prodrugs can be stably entrapped in amphiphilic polyethylene-<i>block</i>-polylactide matrices to form core-shell nanotherapies with augmented colloidal stability. <b>Result2021-01-01T00:00:00Z20212025-04-25T18:39:12.143Z2025-04-06T07:41:24.345ZS-EPMC79774603375405310.7150/thno.54066