{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Zang L"],"pubmed_abstract":["Osteoporosis is the most common aging-associated bone disease and is caused by hyperactivation of osteoclastic activity. We previously reported that the hexane extract of ginger rhizome [ginger hexane extract (GHE)] could suppress receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastogenesis in RAW264.7 cells. However, the anti-osteoclastic components in GHE have not yet been identified. In this study, we separated GHE into several fractions using silica gel column chromatography and evaluated their effects on osteoclastogenesis using a RAW264.7 cell osteoclast differentiation assay (<i>in vitro</i>) and the zebrafish scale model of osteoporosis (<i>in vivo</i>). We identified that the fractions containing 10-gingerol suppressed osteoclastogenesis in RAW264.7 cells"],"journal":["Frontiers in cell and developmental biology"],"pagination":["588093"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7978033"],"repository":["biostudies-literature"],"pubmed_title":["10-Gingerol Suppresses Osteoclastogenesis in RAW264.7 Cells and Zebrafish Osteoporotic Scales."],"pmcid":["PMC7978033"],"pubmed_authors":["Nakayama H","Shimada Y","Zang L","Katsuzaki H","Nishimura N","Kagotani K","Hayashi A","Bhagat J","Fujimoto Y","Sono R"],"additional_accession":[]},"is_claimable":false,"name":"10-Gingerol Suppresses Osteoclastogenesis in RAW264.7 Cells and Zebrafish Osteoporotic Scales.","description":"Osteoporosis is the most common aging-associated bone disease and is caused by hyperactivation of osteoclastic activity. We previously reported that the hexane extract of ginger rhizome [ginger hexane extract (GHE)] could suppress receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastogenesis in RAW264.7 cells. However, the anti-osteoclastic components in GHE have not yet been identified. In this study, we separated GHE into several fractions using silica gel column chromatography and evaluated their effects on osteoclastogenesis using a RAW264.7 cell osteoclast differentiation assay (<i>in vitro</i>) and the zebrafish scale model of osteoporosis (<i>in vivo</i>). We identified that the fractions containing 10-gingerol suppressed osteoclastogenesis in RAW264.7 cells","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-07-16T10:09:56.542Z","creation":"2025-04-06T23:14:29.592Z"},"accession":"S-EPMC7978033","cross_references":{"pubmed":["33748100"],"doi":["10.3389/fcell.2021.588093"]}}