{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang T"],"funding":["NCATS NIH HHS","NIA NIH HHS","NCI NIH HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["1276-1291.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7979509"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(6)"],"pubmed_abstract":["Aberrant cell proliferation is a hallmark of cancer, including glioblastoma (GBM). Here we report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells (GSCs), a subpopulation in GBM critical for malignancy. We identified a casein kinase 2 (CK2)-PRMT6-regulator of chromatin condensation 1 (RCC1) signaling axis whose activity is an important contributor to the stem-like properties and tumor biology of GSCs. CK2 phosphorylates and stabilizes PRMT6 through deubiquitylation, which promotes PRMT6 methylation of RCC1, which in turn is required for RCC1 association with chromatin and activation of RAN. Disruption of this pathway results in defects in mitosis. EPZ020411, a specific small-mole"],"journal":["Molecular cell"],"pubmed_title":["PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells."],"pmcid":["PMC7979509"],"funding_grant_id":["P50 CA221747","UL1 TR001422","R01 NS107071","P30 CA008748","R21 CA209345","R01 CA213293","F31 CA232630","R01 NS102669","R01 AG054429","R01 CA236356","K00 CA234799","R01 NS095642","R01 NS093843","R01 NS095634","P30 CA060553","R01 CA201402","R01 NS115403","R01 NS117104"],"pubmed_authors":["Cheng SY","Goenka A","Wu B","Nakano I","James CD","Wan X","Hu B","Zhang W","Zeng C","Tiek D","Nishikawa R","Huang T","Yang Y","Horbinski CM","Sastry N","Brennan CW","Stupp R","Song X","Xu W","Liu F","Kessler JA","Sulman EP"],"additional_accession":[]},"is_claimable":false,"name":"PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.","description":"Aberrant cell proliferation is a hallmark of cancer, including glioblastoma (GBM). Here we report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells (GSCs), a subpopulation in GBM critical for malignancy. We identified a casein kinase 2 (CK2)-PRMT6-regulator of chromatin condensation 1 (RCC1) signaling axis whose activity is an important contributor to the stem-like properties and tumor biology of GSCs. CK2 phosphorylates and stabilizes PRMT6 through deubiquitylation, which promotes PRMT6 methylation of RCC1, which in turn is required for RCC1 association with chromatin and activation of RAN. Disruption of this pathway results in defects in mitosis. EPZ020411, a specific small-mole","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-31T04:01:40.107Z","creation":"2025-02-19T01:53:14.088Z"},"accession":"S-EPMC7979509","cross_references":{"pubmed":["33539787"],"doi":["10.1016/j.molcel.2021.01.015"]}}