{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ashbrook DG"],"funding":["Swiss National Science Foundation","National Institute on Alcohol Abuse and Alcoholism","European Research Council","NIA NIH HHS","NIDA NIH HHS","NIH Office of the Director","NHLBI NIH HHS","NIAAA NIH HHS","SystemsX.ch","National Institute on Drug Abuse","National Institute on Aging","NIH HHS"],"pagination":["235-247.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7979527"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants-a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for pred"],"journal":["Cell systems"],"pubmed_title":["A platform for experimental precision medicine: The extended BXD mouse family."],"pmcid":["PMC7979527"],"funding_grant_id":["U01 AA014425","U01 AA013499","160318","R01 AG043930","U01 AA016662","787702","P30 DA044223","P40 OD011102","R01 HL151438"],"pubmed_authors":["Lutz CM","Arends D","Valenzuela A","Bohl CJ","Auwerx J","Prins P","Williams RW","Hager R","Williams EG","Centeno AG","Lu L","Ashbrook DG","Ingels JF","Mulligan MK","Roy S","McCarty MS"],"additional_accession":[]},"is_claimable":false,"name":"A platform for experimental precision medicine: The extended BXD mouse family.","description":"The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants-a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for pred","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-31T15:04:30.085Z","creation":"2025-04-06T18:18:57.01Z"},"accession":"S-EPMC7979527","cross_references":{"pubmed":["33472028"],"doi":["10.1016/j.cels.2020.12.002"]}}