{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Moccia C"],"funding":["Italian Ministry for Education, University and Research","Horizon 2020","Compagnia di San Paolo"],"pubmed_abstract":["<h4>Background</h4>Low birthweight has been repeatedly associated with long-term adverse health outcomes and many non-communicable diseases. Our aim was to look-up cord blood birthweight-associated CpG sites identified by the PACE Consortium in infant saliva, and to explore saliva-specific DNA methylation signatures of birthweight.<h4>Methods</h4>DNA methylation was assessed using Infinium HumanMethylation450K array in 135 saliva samples collected from children of the NINFEA birth cohort at an average age of 10.8 (range 7-17) months. The association analyses between birthweight and DNA methylation variations were carried out using robust linear regression models both in the exploratory EWAS analyses and in the look-up of the PACE findings in infant saliva.<h4>Results</h4>None of the cord b"],"journal":["Clinical epigenetics"],"pagination":["57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7980592"],"repository":["biostudies-literature"],"pubmed_title":["Birthweight DNA methylation signatures in infant saliva."],"pmcid":["PMC7980592"],"pubmed_authors":["Trevisan M","Richiardi L","Polidoro S","Popovic M","Rusconi F","Isaevska E","Fiano V","Moccia C"],"additional_accession":[]},"is_claimable":false,"name":"Birthweight DNA methylation signatures in infant saliva.","description":"<h4>Background</h4>Low birthweight has been repeatedly associated with long-term adverse health outcomes and many non-communicable diseases. Our aim was to look-up cord blood birthweight-associated CpG sites identified by the PACE Consortium in infant saliva, and to explore saliva-specific DNA methylation signatures of birthweight.<h4>Methods</h4>DNA methylation was assessed using Infinium HumanMethylation450K array in 135 saliva samples collected from children of the NINFEA birth cohort at an average age of 10.8 (range 7-17) months. The association analyses between birthweight and DNA methylation variations were carried out using robust linear regression models both in the exploratory EWAS analyses and in the look-up of the PACE findings in infant saliva.<h4>Results</h4>None of the cord b","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-20T02:29:04.596Z","creation":"2025-04-20T02:29:04.596Z"},"accession":"S-EPMC7980592","cross_references":{"pubmed":["33741061"],"doi":["10.1186/s13148-021-01053-1"]}}