biostudies-literatureUnknown13(1)Moccia CItalian Ministry for Education, University and ResearchHorizon 2020Compagnia di San Paolo<h4>Background</h4>Low birthweight has been repeatedly associated with long-term adverse health outcomes and many non-communicable diseases. Our aim was to look-up cord blood birthweight-associated CpG sites identified by the PACE Consortium in infant saliva, and to explore saliva-specific DNA methylation signatures of birthweight.<h4>Methods</h4>DNA methylation was assessed using Infinium HumanMethylation450K array in 135 saliva samples collected from children of the NINFEA birth cohort at an average age of 10.8 (range 7-17) months. The association analyses between birthweight and DNA methylation variations were carried out using robust linear regression models both in the exploratory EWAS analyses and in the look-up of the PACE findings in infant saliva.<h4>Results</h4>None of the cord bClinical epigenetics57https://www.ebi.ac.uk/biostudies/studies/S-EPMC7980592biostudies-literatureBirthweight DNA methylation signatures in infant saliva.PMC7980592Trevisan MRichiardi LPolidoro SPopovic MRusconi FIsaevska EFiano VMoccia CfalseBirthweight DNA methylation signatures in infant saliva.<h4>Background</h4>Low birthweight has been repeatedly associated with long-term adverse health outcomes and many non-communicable diseases. Our aim was to look-up cord blood birthweight-associated CpG sites identified by the PACE Consortium in infant saliva, and to explore saliva-specific DNA methylation signatures of birthweight.<h4>Methods</h4>DNA methylation was assessed using Infinium HumanMethylation450K array in 135 saliva samples collected from children of the NINFEA birth cohort at an average age of 10.8 (range 7-17) months. The association analyses between birthweight and DNA methylation variations were carried out using robust linear regression models both in the exploratory EWAS analyses and in the look-up of the PACE findings in infant saliva.<h4>Results</h4>None of the cord b2021-01-01T00:00:00Z2021 Mar2025-04-20T02:29:04.596Z2025-04-20T02:29:04.596ZS-EPMC79805923374106110.1186/s13148-021-01053-1