biostudies-literaturePerez-Sanchez RMinisterio de Ciencia, Innovación y Universidades170https://www.ebi.ac.uk/biostudies/studies/S-EPMC7980729biostudies-literatureUnknown14(1)<h4>Background</h4>The argasid tick Ornithodoros erraticus is the main vector of tick-borne human relapsing fever (TBRF) and African swine fever (ASF) in the Mediterranean Basin. Tick salivary proteins secreted to the host at the feeding interface play critical roles for tick feeding and may contribute to host infection by tick-borne pathogens; accordingly, these proteins represent interesting antigen targets for the development of vaccines aimed at the control and prevention of tick infestations and tick-borne diseases.<h4>Methods</h4>To identify these proteins, the transcriptome of the salivary glands of O. erraticus was de novo assembled and the salivary gene expression dynamics assessed throughout the trophogonic cycle using Illumina sequencing. The genes differentially upregulated aftParasites & vectorsRNA-seq analysis and gene expression dynamics in the salivary glands of the argasid tick Ornithodoros erraticus along the trophogonic cycle.PMC7980729RTI2018-098297-B-I00Soriano BLlorens COleaga ACarnero-Moran APerez-Sanchez RfalseRNA-seq analysis and gene expression dynamics in the salivary glands of the argasid tick Ornithodoros erraticus along the trophogonic cycle.<h4>Background</h4>The argasid tick Ornithodoros erraticus is the main vector of tick-borne human relapsing fever (TBRF) and African swine fever (ASF) in the Mediterranean Basin. Tick salivary proteins secreted to the host at the feeding interface play critical roles for tick feeding and may contribute to host infection by tick-borne pathogens; accordingly, these proteins represent interesting antigen targets for the development of vaccines aimed at the control and prevention of tick infestations and tick-borne diseases.<h4>Methods</h4>To identify these proteins, the transcriptome of the salivary glands of O. erraticus was de novo assembled and the salivary gene expression dynamics assessed throughout the trophogonic cycle using Illumina sequencing. The genes differentially upregulated aft2021-01-01T00:00:00Z2021 Mar2026-04-07T19:17:29.609Z2025-02-19T00:32:56.807ZS-EPMC79807293374377610.1186/s13071-021-04671-z