biostudies-literatureUnknown47(1)Hanaa S MohamedThe present study aimed to synthesis <i>N</i>-substituted-5-(4-chloroquinolin-2-yl)-1,3,4-thiadiazol-2-amine derivatives. Molecular docking study of the synthesized compounds was carried out. COVID-19 docked with the synthesized compounds and the results indicated that the binding energies of docking 6LU7 with native ligand, and the synthesized compounds were -8.1, -8.0, -7.7, -7.5, -7.4, -7.3, -7.2, -6.7, -6.6, -6.5, and -5.4 kcal/mol.<h4>Supplementary information</h4>The online version contains supplementary material available at 10.1134/S1068162021010155.Russian journal of bioorganic chemistry158-165https://www.ebi.ac.uk/biostudies/studies/S-EPMC7980798biostudies-literatureSynthesis, Molecular Docking, In Silico ADME Predictions, and Toxicity Studies of <i>N</i>-Substituted-5-(4-Chloroquinolin-2-yl)-1,3,4-Thiadiazol-2-Amine Derivatives as COVID-19 Inhibitors.PMC7980798Hanaa S MohamedEl-Serwy WSfalseSynthesis, Molecular Docking, In Silico ADME Predictions, and Toxicity Studies of <i>N</i>-Substituted-5-(4-Chloroquinolin-2-yl)-1,3,4-Thiadiazol-2-Amine Derivatives as COVID-19 Inhibitors.The present study aimed to synthesis <i>N</i>-substituted-5-(4-chloroquinolin-2-yl)-1,3,4-thiadiazol-2-amine derivatives. Molecular docking study of the synthesized compounds was carried out. COVID-19 docked with the synthesized compounds and the results indicated that the binding energies of docking 6LU7 with native ligand, and the synthesized compounds were -8.1, -8.0, -7.7, -7.5, -7.4, -7.3, -7.2, -6.7, -6.6, -6.5, and -5.4 kcal/mol.<h4>Supplementary information</h4>The online version contains supplementary material available at 10.1134/S1068162021010155.2021-01-01T00:00:00Z20212026-05-03T09:27:51.853Z2022-02-09T10:18:03.611ZS-EPMC79807983377639510.1134/S1068162021010155