biostudies-literatureUnknown18(1)Ricci SThe sample collection procedure for SARS-CoV-2 has a strong impact on diagnostic capability, contact tracing approach, ultimately affecting the infection containment performance. This study demonstrates that self-collected nasal-swab has shown to be a valid and well tolerated procedure to SARS-CoV-2 surveillance in a healthcare system. More significantly, no performance adequacy difference was detected in self-administered swabs between healthcare worker (HCW) and non-HCW which allows to speculate that this procedure could be successfully extended to the entire population for mass screening.Virology journal59https://www.ebi.ac.uk/biostudies/studies/S-EPMC7980800biostudies-literatureHow home anterior self-collected nasal swab simplifies SARS-CoV-2 testing: new surveillance horizons in public health and beyond.PMC7980800Resti MZanobini ANieddu FRicci SGuarnieri VIndolfi GAzzari CGiovannini MMoriondo MLodi LCitera FfalseHow home anterior self-collected nasal swab simplifies SARS-CoV-2 testing: new surveillance horizons in public health and beyond.The sample collection procedure for SARS-CoV-2 has a strong impact on diagnostic capability, contact tracing approach, ultimately affecting the infection containment performance. This study demonstrates that self-collected nasal-swab has shown to be a valid and well tolerated procedure to SARS-CoV-2 surveillance in a healthcare system. More significantly, no performance adequacy difference was detected in self-administered swabs between healthcare worker (HCW) and non-HCW which allows to speculate that this procedure could be successfully extended to the entire population for mass screening.2021-01-01T00:00:00Z2021 Mar2025-04-04T20:58:05.206Z2025-02-19T00:33:52.803ZS-EPMC79808003374371110.1186/s12985-021-01533-z