{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["100(11)"],"submitter":["Xiao W"],"pubmed_abstract":["<h4>Background</h4>Chemotherapy in combination with thoracic radiotherapy yields significant results in patients with advanced non-small-cell lung cancer (NSCLC) compared with thoracic radiotherapy alone. However, whether concurrent or sequential delivery of chemotherapy combined with thoracic radiotherapy is optimal remains unclear. Herein, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of concurrent vs sequential chemoradiotherapy in patients with NSCLC.<h4>Methods</h4>PubMed, EmBase, and Cochrane Library were systematically searched for RCTs focusing on concurrent and sequential chemoradiotherapy for patients with NSCLC. The pooled-effect estimate was calculated using the random-effects model. Sensitivity, su"],"journal":["Medicine"],"pagination":["e21455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7982214"],"repository":["biostudies-literature"],"pubmed_title":["Concurrent vs sequential chemoradiotherapy for patients with advanced non-small-cell lung cancer: A meta-analysis of randomized controlled trials."],"pmcid":["PMC7982214"],"pubmed_authors":["Hong M","Xiao W"],"additional_accession":[]},"is_claimable":false,"name":"Concurrent vs sequential chemoradiotherapy for patients with advanced non-small-cell lung cancer: A meta-analysis of randomized controlled trials.","description":"<h4>Background</h4>Chemotherapy in combination with thoracic radiotherapy yields significant results in patients with advanced non-small-cell lung cancer (NSCLC) compared with thoracic radiotherapy alone. However, whether concurrent or sequential delivery of chemotherapy combined with thoracic radiotherapy is optimal remains unclear. Herein, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of concurrent vs sequential chemoradiotherapy in patients with NSCLC.<h4>Methods</h4>PubMed, EmBase, and Cochrane Library were systematically searched for RCTs focusing on concurrent and sequential chemoradiotherapy for patients with NSCLC. The pooled-effect estimate was calculated using the random-effects model. Sensitivity, su","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-21T23:33:14.608Z","creation":"2025-04-05T19:14:22.509Z"},"accession":"S-EPMC7982214","cross_references":{"pubmed":["33725921"],"doi":["10.1097/MD.0000000000021455"]}}