biostudies-literatureChroumpi TAcademy of FinlandDutch Research Council (NWO)644216https://www.ebi.ac.uk/biostudies/studies/S-EPMC7982397biostudies-literatureUnknown9The filamentous ascomycete <i>Aspergillus niger</i> has received increasing interest as a cell factory, being able to efficiently degrade plant cell wall polysaccharides as well as having an extensive metabolism to convert the released monosaccharides into value added compounds. The pentoses D-xylose and L-arabinose are the most abundant monosaccharides in plant biomass after the hexose D-glucose, being major constituents of xylan, pectin and xyloglucan. In this study, the influence of selected pentose catabolic pathway (PCP) deletion strains on growth on plant biomass and re-routing of sugar catabolism was addressed to gain a better understanding of the flexibility of this fungus in using plant biomass-derived monomers. The transcriptome, metabolome and proteome response of three PCP mutaFrontiers in bioengineering and biotechnologyRe-routing of Sugar Catabolism Provides a Better Insight Into Fungal Flexibility in Using Plant Biomass-Derived Monomers as Substrates.PMC7982397ALWOP.233Tolic NClendinen CSMarkillie LMMitchell HDNicora CDOrr GMakela MRde Vries RPPaurus VChroumpi TPeng MHutchinson CMBaker SEfalseRe-routing of Sugar Catabolism Provides a Better Insight Into Fungal Flexibility in Using Plant Biomass-Derived Monomers as Substrates.The filamentous ascomycete <i>Aspergillus niger</i> has received increasing interest as a cell factory, being able to efficiently degrade plant cell wall polysaccharides as well as having an extensive metabolism to convert the released monosaccharides into value added compounds. The pentoses D-xylose and L-arabinose are the most abundant monosaccharides in plant biomass after the hexose D-glucose, being major constituents of xylan, pectin and xyloglucan. In this study, the influence of selected pentose catabolic pathway (PCP) deletion strains on growth on plant biomass and re-routing of sugar catabolism was addressed to gain a better understanding of the flexibility of this fungus in using plant biomass-derived monomers. The transcriptome, metabolome and proteome response of three PCP muta2021-01-01T00:00:00Z20212026-04-07T19:24:10.569Z2024-11-13T06:29:37.735ZS-EPMC79823973376341110.3389/fbioe.2021.644216