{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stegwee SI"],"funding":["ZonMw"],"pagination":["866-878"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7983985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["128(5)"],"pubmed_abstract":["<h4>Objective</h4>To evaluate whether double-layer uterine closure after a first caesarean section (CS) is superior compared with single-layer uterine closure in terms of postmenstrual spotting and niche development in the uterine caesarean scar.<h4>Design</h4>Multicentre, double-blind, randomised controlled superiority trial.<h4>Setting</h4>Thirty-two hospitals in the Netherlands.<h4>Population</h4>A total of 2292 women aged ≥18 years undergoing a first CS were randomly assigned to each procedure (1:1): 1144 women were assigned to single-layer uterine closure and 1148 women were assigned to double-layer uterine closure.<h4>Methods</h4>Single-layer unlocked closure and double-layer unlocked closure, with the second layer imbricating the first.<h4>Main outcome measures</h4>Number of days wi"],"journal":["BJOG : an international journal of obstetrics and gynaecology"],"pubmed_title":["Effect of single- versus double-layer uterine closure during caesarean section on postmenstrual spotting (2Close): multicentre, double-blind, randomised controlled superiority trial."],"pmcid":["PMC7983985"],"funding_grant_id":["843002605"],"pubmed_authors":["Bekker MN","van Kesteren PJ","de Boer K","van de Ven PM","Huirne J","El Alili M","Feitsma AH","de Leeuw RA","de Vleeschouwer LM","Meijer WJ","Scheepers HL","Janssen CI","Huisjes AJ","van Laar JO","van der Voet L","Langenveld J","van Baal WM","Radder CM","2Close study group","Hink E","Visser H","Ben AJ","Bongers MY","Hermes W","Rijnders RJ","van der Voet LF","van Beek E","de Groot C","Hemelaar M","Sueters M","van Vliet HA","Pajkrt E","Schippers DH","Lambalk CB","Bosmans JE","Boormans EM","van Eijndhoven HW","Papatsonis DN","Oei AL","Stegwee SI","Hehenkamp WJ","Schuitemaker NW","Kapiteijn K","Duijnhoven RG","Kaplan M"],"additional_accession":[]},"is_claimable":false,"name":"Effect of single- versus double-layer uterine closure during caesarean section on postmenstrual spotting (2Close): multicentre, double-blind, randomised controlled superiority trial.","description":"<h4>Objective</h4>To evaluate whether double-layer uterine closure after a first caesarean section (CS) is superior compared with single-layer uterine closure in terms of postmenstrual spotting and niche development in the uterine caesarean scar.<h4>Design</h4>Multicentre, double-blind, randomised controlled superiority trial.<h4>Setting</h4>Thirty-two hospitals in the Netherlands.<h4>Population</h4>A total of 2292 women aged ≥18 years undergoing a first CS were randomly assigned to each procedure (1:1): 1144 women were assigned to single-layer uterine closure and 1148 women were assigned to double-layer uterine closure.<h4>Methods</h4>Single-layer unlocked closure and double-layer unlocked closure, with the second layer imbricating the first.<h4>Main outcome measures</h4>Number of days wi","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-18T17:41:00.734Z","creation":"2025-04-07T05:17:50.861Z"},"accession":"S-EPMC7983985","cross_references":{"pubmed":["32892392"],"doi":["10.1111/1471-0528.16472"]}}