biostudies-literatureStegwee SIZonMw866-878https://www.ebi.ac.uk/biostudies/studies/S-EPMC7983985biostudies-literatureUnknown128(5)<h4>Objective</h4>To evaluate whether double-layer uterine closure after a first caesarean section (CS) is superior compared with single-layer uterine closure in terms of postmenstrual spotting and niche development in the uterine caesarean scar.<h4>Design</h4>Multicentre, double-blind, randomised controlled superiority trial.<h4>Setting</h4>Thirty-two hospitals in the Netherlands.<h4>Population</h4>A total of 2292 women aged ≥18 years undergoing a first CS were randomly assigned to each procedure (1:1): 1144 women were assigned to single-layer uterine closure and 1148 women were assigned to double-layer uterine closure.<h4>Methods</h4>Single-layer unlocked closure and double-layer unlocked closure, with the second layer imbricating the first.<h4>Main outcome measures</h4>Number of days wiBJOG : an international journal of obstetrics and gynaecologyEffect of single- versus double-layer uterine closure during caesarean section on postmenstrual spotting (2Close): multicentre, double-blind, randomised controlled superiority trial.PMC7983985843002605Bekker MNvan Kesteren PJde Boer Kvan de Ven PMHuirne JEl Alili MFeitsma AHde Leeuw RAde Vleeschouwer LMMeijer WJScheepers HLJanssen CIHuisjes AJvan Laar JOvan der Voet LLangenveld Jvan Baal WMRadder CM2Close study groupHink EVisser HBen AJBongers MYHermes WRijnders RJvan der Voet LFvan Beek Ede Groot CHemelaar MSueters Mvan Vliet HAPajkrt ESchippers DHLambalk CBBosmans JEBoormans EMvan Eijndhoven HWPapatsonis DNOei ALStegwee SIHehenkamp WJSchuitemaker NWKapiteijn KDuijnhoven RGKaplan MfalseEffect of single- versus double-layer uterine closure during caesarean section on postmenstrual spotting (2Close): multicentre, double-blind, randomised controlled superiority trial.<h4>Objective</h4>To evaluate whether double-layer uterine closure after a first caesarean section (CS) is superior compared with single-layer uterine closure in terms of postmenstrual spotting and niche development in the uterine caesarean scar.<h4>Design</h4>Multicentre, double-blind, randomised controlled superiority trial.<h4>Setting</h4>Thirty-two hospitals in the Netherlands.<h4>Population</h4>A total of 2292 women aged ≥18 years undergoing a first CS were randomly assigned to each procedure (1:1): 1144 women were assigned to single-layer uterine closure and 1148 women were assigned to double-layer uterine closure.<h4>Methods</h4>Single-layer unlocked closure and double-layer unlocked closure, with the second layer imbricating the first.<h4>Main outcome measures</h4>Number of days wi2021-01-01T00:00:00Z2021 Apr2025-04-18T17:41:00.734Z2025-04-07T05:17:50.861ZS-EPMC79839853289239210.1111/1471-0528.16472