{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rauch SAM"],"funding":["NCATS NIH HHS","U.S. Department of Defense","National Institutes of Health"],"pagination":["104714"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7984524"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118"],"pubmed_abstract":["PTSD is associated with abnormalities in hypothalamic-pituitary-adrenal (HPA) axis activity. This includes enhanced HPA axis negative feedback, attenuated cortisol awakening response, and attenuated cortisol response to personal trauma script. Whether HPA axis function predicts treatment response or treatment related symptom reduction in PTSD remains unclear. In addition, the relative effects of different treatment modalities (i.e., medication and psychotherapy) on HPA axis is unclear. To address this gap in knowledge, the PROGrESS study examined cortisol awakening response across treatment in Veterans with chronic PTSD randomized to receive Prolonged Exposure + Placebo (PE + PLB), Sertraline + PE (SERT + PE) or Sertraline + Enhanced Medication Management (SERT + EMM). Salivary cortisol aw"],"journal":["Psychoneuroendocrinology"],"pubmed_title":["Cortisol awakening response in PTSD treatment: Predictor or mechanism of change."],"pmcid":["PMC7984524"],"funding_grant_id":["UL1 TR000433"],"pubmed_authors":["Kim HM","Powell C","Rauch SAM","Simon NM","Rajaram N","Hamner M","Liberzon I","King A","Venners M"],"additional_accession":[]},"is_claimable":false,"name":"Cortisol awakening response in PTSD treatment: Predictor or mechanism of change.","description":"PTSD is associated with abnormalities in hypothalamic-pituitary-adrenal (HPA) axis activity. This includes enhanced HPA axis negative feedback, attenuated cortisol awakening response, and attenuated cortisol response to personal trauma script. Whether HPA axis function predicts treatment response or treatment related symptom reduction in PTSD remains unclear. In addition, the relative effects of different treatment modalities (i.e., medication and psychotherapy) on HPA axis is unclear. To address this gap in knowledge, the PROGrESS study examined cortisol awakening response across treatment in Veterans with chronic PTSD randomized to receive Prolonged Exposure + Placebo (PE + PLB), Sertraline + PE (SERT + PE) or Sertraline + Enhanced Medication Management (SERT + EMM). Salivary cortisol aw","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-21T18:24:55.911Z","creation":"2025-04-05T17:15:05.726Z"},"accession":"S-EPMC7984524","cross_references":{"pubmed":["32446108"],"doi":["10.1016/j.psyneuen.2020.104714"]}}