biostudies-literatureAdler SCCR NIH HHSIntramural NIH HHSLeidos biomedical Research IncNCI NIH HHSNational Cancer Institute Invention Development FundNational Cancer Institute, National Institutes of Health185004https://www.ebi.ac.uk/biostudies/studies/S-EPMC7984724biostudies-literatureUnknown63(18)A new class of dose calibrator called a micro-dose calibrator, designed to measure radioactivity rates in the range between 1 kBq up to 370 kBq, has been designed and an 8 NaI(Tl)/photo multiplier tube (PMT) module prototype built to evaluate its performance. The design of the micro-dose calibrator is based on the concept of a segmented well counter. By segmenting a single crystal well counter into multiple crystals or segments, with each segment operated and read out independently, one can extend the operational range of a standard single crystal well counter while maintaining its accuracy and spectrographic capabilities. The micro-dose calibrator is operated in N-fold coincidence mode to ensure that a single radioactive decay resulting in multiple segments detecting gamma ray events are Physics in medicine and biologyDesign and performance of the micro-dose calibrator.PMC79847242017 Laboratory Directed ExploratorHHSN261200800001EHHSN261200800001CZ01 BC010668Adler SChoyke PfalseDesign and performance of the micro-dose calibrator.A new class of dose calibrator called a micro-dose calibrator, designed to measure radioactivity rates in the range between 1 kBq up to 370 kBq, has been designed and an 8 NaI(Tl)/photo multiplier tube (PMT) module prototype built to evaluate its performance. The design of the micro-dose calibrator is based on the concept of a segmented well counter. By segmenting a single crystal well counter into multiple crystals or segments, with each segment operated and read out independently, one can extend the operational range of a standard single crystal well counter while maintaining its accuracy and spectrographic capabilities. The micro-dose calibrator is operated in N-fold coincidence mode to ensure that a single radioactive decay resulting in multiple segments detecting gamma ray events are 2018-01-01T00:00:00Z2018 Sep2025-04-05T13:48:26.835Z2025-04-05T13:48:26.835ZS-EPMC79847243011844010.1088/1361-6560/aadb3b