biostudies-literatureUnknown52Sun GScience and Technology Commission of Shanghai MunicipalityThe current COVID-19 pandemic is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). By late October 2020, more than 43 million cases of infections, including over 1.15 million deaths, have been confirmed worldwide. This review focuses on our current understanding of SARS-CoV-2 from the perspective of the three-dimensional (3D) structures of SARS-CoV-2 viral proteins and their implications on therapeutics development against COVID-19.Stem cell research102219https://www.ebi.ac.uk/biostudies/studies/S-EPMC7985237biostudies-literatureStructural insights into SARS-CoV-2 infection and therapeutics development.PMC7985237Xue LSun GHe QXu WWang ZZhao YfalseStructural insights into SARS-CoV-2 infection and therapeutics development.The current COVID-19 pandemic is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). By late October 2020, more than 43 million cases of infections, including over 1.15 million deaths, have been confirmed worldwide. This review focuses on our current understanding of SARS-CoV-2 from the perspective of the three-dimensional (3D) structures of SARS-CoV-2 viral proteins and their implications on therapeutics development against COVID-19.2021-01-01T00:00:00Z2021 Apr2025-04-18T16:05:07.584Z2025-02-18T23:35:39.059ZS-EPMC79852373355014010.1016/j.scr.2021.102219