biostudies-literatureUnknown11(1)Mengozzi AHigh sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). We then explored the relevance of these pathways in defining mortality and complications risk and the potential effects of the treatments to attenuate such risk. In this single-center, prospective, observational study we enrolled 266 consecutive patients hospitalized for SARS-CoV-2 pneumonia. Primary endpoint was in-hospital COVID-19 mortality. hsTnT, even after adjustment for confounders, was associated with mortality. D-dimer and CRP presented stronger associations with hsTnT than Scientific reports6515https://www.ebi.ac.uk/biostudies/studies/S-EPMC7985490biostudies-literatureThe relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome.PMC7985490Simone PAlessandro CSantini MAlessandra DRValentina GCarrozzi LRachele AMasi SChiara SMartina BChiara PStefano SGiovanna FGeorgiopoulos GDimopoulos MAPietro BVirdis AFabio GNaria PRubia BSabrina AODValeria CFalcone MPaolo MMonzani FElia NMarco MLuciano CForfori FTiseo GUliana MMaria SFrancesco CPugliese NRMengozzi APisa Covid Study GroupGiulia BFrancesca RMenichetti FMatteo BGhiadoni LDe Marco SBarbieri GfalseThe relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome.High sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). We then explored the relevance of these pathways in defining mortality and complications risk and the potential effects of the treatments to attenuate such risk. In this single-center, prospective, observational study we enrolled 266 consecutive patients hospitalized for SARS-CoV-2 pneumonia. Primary endpoint was in-hospital COVID-19 mortality. hsTnT, even after adjustment for confounders, was associated with mortality. D-dimer and CRP presented stronger associations with hsTnT than 2021-01-01T00:00:00Z2021 Mar2025-04-04T08:27:21.631Z2025-02-18T23:54:26.563ZS-EPMC79854903375375910.1038/s41598-021-85646-z