biostudies-literatureRysavy MAU.S. Department of Health &amp; Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NICHD NIH HHSNCATS NIH HHSU.S. Department of Health &amp; Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development2270-2278https://www.ebi.ac.uk/biostudies/studies/S-EPMC7985590biostudies-literatureUnknown41(9)<h4>Objective</h4>Determine how neurodevelopmental impairment (NDI) relates to concurrent outcomes for children born extremely preterm.<h4>Study design</h4>Retrospective cohort study children born 22 0/7-26 6/7 weeks' gestation at NICHD Neonatal Research Network hospitals. Outcomes were ascertained at 18-22 months' corrected age.<h4>Result</h4>Of 6562 children, 2618 (40%) died and 441 (7%) had no follow-up. Among the remaining 3483 children, 825 (24%), 1576 (45%), 657 (19%), and 425 (12%) had no, potential/mild, moderate, and severe NDI, respectively. Rehospitalization, respiratory medications, surgery, and medical support services were associated with greater NDI severity but affected >10% of children without NDI. Rehospitalization occurred in 40% of children with no NDI (mean (SD): 1.7 (Journal of perinatology : official journal of the California Perinatal AssociationThe relationship of neurodevelopmental impairment to concurrent early childhood outcomes of extremely preterm infants.PMC7985590UG1 HD027904U10 HD53109U10HD68244U10HD27880U10HD34216U10 HD027904UL1 TR003167U10 HD053109F32HD098782U24 HD095254UG1 HD087226U10HD53109Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research NetworkColaizy TTJohnson KJVohr BRBrumbaugh JEBell EFBann CMDeMauro SBDuncan AFPeralta-Carcelen MHarmon HMRysavy MAHintz SRfalseThe relationship of neurodevelopmental impairment to concurrent early childhood outcomes of extremely preterm infants.<h4>Objective</h4>Determine how neurodevelopmental impairment (NDI) relates to concurrent outcomes for children born extremely preterm.<h4>Study design</h4>Retrospective cohort study children born 22 0/7-26 6/7 weeks' gestation at NICHD Neonatal Research Network hospitals. Outcomes were ascertained at 18-22 months' corrected age.<h4>Result</h4>Of 6562 children, 2618 (40%) died and 441 (7%) had no follow-up. Among the remaining 3483 children, 825 (24%), 1576 (45%), 657 (19%), and 425 (12%) had no, potential/mild, moderate, and severe NDI, respectively. Rehospitalization, respiratory medications, surgery, and medical support services were associated with greater NDI severity but affected >10% of children without NDI. Rehospitalization occurred in 40% of children with no NDI (mean (SD): 1.7 (2021-01-01T00:00:00Z2021 Sep2025-04-21T23:38:11.178Z2025-04-05T19:12:55.182ZS-EPMC79855903375838910.1038/s41372-021-00999-7