{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Miller JJ"],"funding":["British Heart Foundation","National Institute for Health Research (NIHR)","Wellcome Trust","Engineering and Physical Sciences Research Council"],"pagination":["2978-2991"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7986077"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["85(6)"],"pubmed_abstract":["Purpose
Phosphorus saturation-transfer experiments can quantify metabolic fluxes noninvasively. Typically, the forward flux through the creatine kinase reaction is investigated by observing the decrease in phosphocreatine (PCr) after saturation of γ-ATP. The quantification of total ATP utilization is currently underexplored, as it requires simultaneous saturation of inorganic phosphate ( Pi ) and PCr. This is challenging, as currently available saturation pulses reduce the already-low γ-ATP signal present.Methods
Using a hybrid optimal-control and Shinnar-Le Roux method, a quasi-adiabatic RF pulse was designed for the dual saturation of PCr and Pi to enable determination of total ATP utilization. The pulses were evaluated in Bloch equation simulations, compared with a conve"],"journal":["Magnetic resonance in medicine"],"pubmed_title":["Rapid, B1 -insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux."],"pmcid":["PMC7986077"],"funding_grant_id":["FS/14/17/30634","FS/19/18/34252","FS/15/68/32042","1944425","RE/13/1/30181","FS/16/7/31843","FS/17/58/33072","098436/Z/12/B","RG/11/9/28921"],"pubmed_authors":["Tyler DJ","Tyler A","Timm KN","Lau JYC","Miller JJ","Kerr M","Watson WD","Bottomley PA","Valkovic L","Heather LC","Rodgers C"],"additional_accession":[]},"is_claimable":false,"name":"Rapid, B1 -insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux.","description":"Purpose
Phosphorus saturation-transfer experiments can quantify metabolic fluxes noninvasively. Typically, the forward flux through the creatine kinase reaction is investigated by observing the decrease in phosphocreatine (PCr) after saturation of γ-ATP. The quantification of total ATP utilization is currently underexplored, as it requires simultaneous saturation of inorganic phosphate ( Pi ) and PCr. This is challenging, as currently available saturation pulses reduce the already-low γ-ATP signal present.Methods
Using a hybrid optimal-control and Shinnar-Le Roux method, a quasi-adiabatic RF pulse was designed for the dual saturation of PCr and Pi to enable determination of total ATP utilization. The pulses were evaluated in Bloch equation simulations, compared with a conve","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-18T17:41:14.766Z","creation":"2025-04-07T05:18:05.823Z"},"accession":"S-EPMC7986077","cross_references":{"pubmed":["33538063"],"doi":["10.1002/mrm.28647"]}}