{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Reithofer M"],"funding":["Austrian Science Fund FWF"],"pagination":["721-733"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7986150"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(3)"],"pubmed_abstract":["Costimulatory signals potently promote T-cell proliferation and effector function. Agonistic antibodies targeting costimulatory receptors of the TNFR family, such as 4-1BB and CD27, have entered clinical trials in cancer patients. Currently there is limited information how costimulatory signals regulate antigen-specific but also bystander activation of human CD8 T cells. Engineered antigen presenting cells (eAPC) efficiently presenting several common viral epitopes on HLA-A2 in combination with MHC class I tetramer staining were used to investigate the impact of costimulatory signals on human CD8 T-cell responses. CD28 costimulation potently augmented the percentage and number of antigen-reactive CD8 T cells, whereas eAPC expressing 4-1BB-ligand induced bystander proliferation of CD8 T cel"],"journal":["European journal of immunology"],"pubmed_title":["4-1BB costimulation promotes bystander activation of human CD8 T cells."],"pmcid":["PMC7986150"],"funding_grant_id":["MCCA‐W1248","SFB‐F4610","FWF‐P32411"],"pubmed_authors":["Jahn-Schmid B","Leitner J","Rosskopf S","Battin C","Bohle B","Reithofer M","Steinberger P"],"additional_accession":[]},"is_claimable":false,"name":"4-1BB costimulation promotes bystander activation of human CD8 T cells.","description":"Costimulatory signals potently promote T-cell proliferation and effector function. Agonistic antibodies targeting costimulatory receptors of the TNFR family, such as 4-1BB and CD27, have entered clinical trials in cancer patients. Currently there is limited information how costimulatory signals regulate antigen-specific but also bystander activation of human CD8 T cells. Engineered antigen presenting cells (eAPC) efficiently presenting several common viral epitopes on HLA-A2 in combination with MHC class I tetramer staining were used to investigate the impact of costimulatory signals on human CD8 T-cell responses. CD28 costimulation potently augmented the percentage and number of antigen-reactive CD8 T cells, whereas eAPC expressing 4-1BB-ligand induced bystander proliferation of CD8 T cel","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-05T15:24:32.196Z","creation":"2025-04-05T15:24:32.196Z"},"accession":"S-EPMC7986150","cross_references":{"pubmed":["33180337"],"doi":["10.1002/eji.202048762"]}}