biostudies-literatureKubota Sa Grant for Strategic Research Promotion from Yokohama City UniversityGrants-in-Aid for Scientific Researcha Health and Labor Sciences Research Grant from the Ministry of Health, Labour and Welfare, JapanTakeda Science FoundationGrants-in-Aid for Young Scientists59https://www.ebi.ac.uk/biostudies/studies/S-EPMC7986274biostudies-literatureUnknown14(1)Intracellular aggregates are a common pathological hallmark of neurodegenerative diseases such as polyglutamine (polyQ) diseases, amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and multiple system atrophy (MSA). Aggregates are mainly formed by aberrant disease-specific proteins and are accompanied by accumulation of other aggregate-interacting proteins. Although aggregate-interacting proteins have been considered to modulate the formation of aggregates and to be involved in molecular mechanisms of disease progression, the components of aggregate-interacting proteins remain unknown. In this study, we showed that small glutamine-rich tetratricopeptide repeat-containing protein alfa (SGTA) is an aggregate-interacting protein in neurodegenerative diseases. Immunohistochemistry Molecular brainSGTA associates with intracellular aggregates in neurodegenerative diseases.PMC798627420K16581#SK2804#201711060A18K0753119K0784518K0753218K0750319K1701418K07504Tanaka FNakamura HIkeda SKunii MKubota STada MKoyano SDoi HKatsumoto AFukai RTakeuchi HTanaka KKomiya HTakahashi KHashiguchi SfalseSGTA associates with intracellular aggregates in neurodegenerative diseases.Intracellular aggregates are a common pathological hallmark of neurodegenerative diseases such as polyglutamine (polyQ) diseases, amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and multiple system atrophy (MSA). Aggregates are mainly formed by aberrant disease-specific proteins and are accompanied by accumulation of other aggregate-interacting proteins. Although aggregate-interacting proteins have been considered to modulate the formation of aggregates and to be involved in molecular mechanisms of disease progression, the components of aggregate-interacting proteins remain unknown. In this study, we showed that small glutamine-rich tetratricopeptide repeat-containing protein alfa (SGTA) is an aggregate-interacting protein in neurodegenerative diseases. Immunohistochemistry 2021-01-01T00:00:00Z2021 Mar2025-04-22T10:47:04.901Z2025-04-05T23:40:17.066ZS-EPMC79862743375757510.1186/s13041-021-00770-1