biostudies-literatureConway MCNIEHS NIH HHSDepartment for Employment and Learning, Northern IrelandNational Institutes of HealthSwedish Research Council FORMASNIH HHSKarolinska Institutet, Sweden1415-1427https://www.ebi.ac.uk/biostudies/studies/S-EPMC7987591biostudies-literatureUnknown60(3)<h4>Purpose</h4>Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and α-linolenic acid (ALA) in a pathway involving the fatty acid desaturase (FADS) genes. Endogenous synthesis is inefficient; therefore, dietary intake of preformed LCPUFA from their richest source of fish is preferred. This study investigated the effect of fish consumption on PUFA concentrations in women of childbearing age while stratifying by FADS genotype. The influence of fish consumption on lipid profile, and markers of inflammation and oxidative stress was also examined.<h4>Methods</h4>Healthy women (n = 49) provided a buccal swab which was analysed for FADS2 genotype (rs3834458; T/deletion). Participants were stratified according to genotype and randomised to an European journal of nutritionThe influence of fish consumption on serum n-3 polyunsaturated fatty acid (PUFA) concentrations in women of childbearing age: a randomised controlled trial (the iFish Study).PMC7987591R01-ES010219P30 ES001247P30-ES01247R01 ES010219Watson GEHyland BWWijngaarden EVSpence TPineda DWahlberg KYeates AJConway MCCobice DFMcSorley EMStrain JJMulhern MSBroberg KfalseThe influence of fish consumption on serum n-3 polyunsaturated fatty acid (PUFA) concentrations in women of childbearing age: a randomised controlled trial (the iFish Study).<h4>Purpose</h4>Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and α-linolenic acid (ALA) in a pathway involving the fatty acid desaturase (FADS) genes. Endogenous synthesis is inefficient; therefore, dietary intake of preformed LCPUFA from their richest source of fish is preferred. This study investigated the effect of fish consumption on PUFA concentrations in women of childbearing age while stratifying by FADS genotype. The influence of fish consumption on lipid profile, and markers of inflammation and oxidative stress was also examined.<h4>Methods</h4>Healthy women (n = 49) provided a buccal swab which was analysed for FADS2 genotype (rs3834458; T/deletion). Participants were stratified according to genotype and randomised to an 2021-01-01T00:00:00Z2021 Apr2026-05-02T18:00:33.127Z2022-02-09T16:00:55.407ZS-EPMC79875913272529310.1007/s00394-020-02326-w