{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["National Natural Science Foundation of China","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["126"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7987995"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["The efficient induction and long-term persistence of pathogen-specific memory CD8 T cells are pivotal to rapidly curb the reinfection. Recent studies indicated that long-noncoding RNAs expression is highly cell- and stage-specific during T cell development and differentiation, suggesting their potential roles in T cell programs. However, the key lncRNAs playing crucial roles in memory CD8 T cell establishment remain to be clarified. Through CD8 T cell subsets profiling of lncRNAs, this study found a key lncRNA-Snhg1 with the conserved naive<sup>hi</sup>-effector<sup>lo</sup>-memory<sup>hi</sup> expression pattern in CD8 T cells of both mice and human, that can promote memory formation while impeding effector CD8 in acute viral infection. Further, Snhg1 was found interacting with the conser"],"journal":["Signal transduction and targeted therapy"],"pubmed_title":["The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling."],"pmcid":["PMC7987995"],"funding_grant_id":["31800763","2016YFA0502202"],"pubmed_authors":["Yue S","Wu J","Jiang L","Yang L","Ni T","Huang Q","Zhou X","Ye L","Wang P","Li Z","Bai Q","Zhang Y","Li B","Wei G","Hu L","Wang Z","Wu Y","Tian Q","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling.","description":"The efficient induction and long-term persistence of pathogen-specific memory CD8 T cells are pivotal to rapidly curb the reinfection. Recent studies indicated that long-noncoding RNAs expression is highly cell- and stage-specific during T cell development and differentiation, suggesting their potential roles in T cell programs. However, the key lncRNAs playing crucial roles in memory CD8 T cell establishment remain to be clarified. Through CD8 T cell subsets profiling of lncRNAs, this study found a key lncRNA-Snhg1 with the conserved naive<sup>hi</sup>-effector<sup>lo</sup>-memory<sup>hi</sup> expression pattern in CD8 T cells of both mice and human, that can promote memory formation while impeding effector CD8 in acute viral infection. Further, Snhg1 was found interacting with the conser","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-05T16:17:07.262Z","creation":"2022-02-09T15:46:27.457Z"},"accession":"S-EPMC7987995","cross_references":{"pubmed":["33758164"],"doi":["10.1038/s41392-021-00492-9"]}}