biostudies-literatureZhang YNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (National Science Foundation of China)126https://www.ebi.ac.uk/biostudies/studies/S-EPMC7987995biostudies-literatureUnknown6(1)The efficient induction and long-term persistence of pathogen-specific memory CD8 T cells are pivotal to rapidly curb the reinfection. Recent studies indicated that long-noncoding RNAs expression is highly cell- and stage-specific during T cell development and differentiation, suggesting their potential roles in T cell programs. However, the key lncRNAs playing crucial roles in memory CD8 T cell establishment remain to be clarified. Through CD8 T cell subsets profiling of lncRNAs, this study found a key lncRNA-Snhg1 with the conserved naive^hi-effector^lo-memory^hi expression pattern in CD8 T cells of both mice and human, that can promote memory formation while impeding effector CD8 in acute viral infection. Further, Snhg1 was found interacting with the conserSignal transduction and targeted therapyThe lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling.PMC7987995318007632016YFA0502202Yue SWu JJiang LYang LNi THuang QZhou XYe LWang PLi ZBai QZhang YLi BWei GHu LWang ZWu YTian QZhou JfalseThe lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling.The efficient induction and long-term persistence of pathogen-specific memory CD8 T cells are pivotal to rapidly curb the reinfection. Recent studies indicated that long-noncoding RNAs expression is highly cell- and stage-specific during T cell development and differentiation, suggesting their potential roles in T cell programs. However, the key lncRNAs playing crucial roles in memory CD8 T cell establishment remain to be clarified. Through CD8 T cell subsets profiling of lncRNAs, this study found a key lncRNA-Snhg1 with the conserved naive^hi-effector^lo-memory^hi expression pattern in CD8 T cells of both mice and human, that can promote memory formation while impeding effector CD8 in acute viral infection. Further, Snhg1 was found interacting with the conser2021-01-01T00:00:00Z2021 Mar2025-04-05T16:17:07.262Z2022-02-09T15:46:27.457ZS-EPMC79879953375816410.1038/s41392-021-00492-9