{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Dakik H"],"pubmed_abstract":["Advances in large-scale proteomics analysis have been very useful in understanding pathogenesis of diseases and elaborating therapeutic strategies. Proteomics has been employed to study Parkinson disease (PD); however, sparse studies reported proteome investigation after cell therapy approaches. In this study, we used liquid chromatography-tandem mass spectrometry and systems biology to identify differentially expressed proteins in a translational mouse model of PD after cell therapy. Proteins were extracted from five nigrostriatal-related brain regions of mice previously lesioned with 6-hydroxydopamine in the substantia nigra. Protein expression was compared in non-grafted brain to 1 and 7 days after intranigral grafting of E12.5 embryonic ventral mesencephalon (VM). We found a total of 2"],"journal":["Frontiers in neuroscience"],"pagination":["621121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7991918"],"repository":["biostudies-literature"],"pubmed_title":["Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease."],"pmcid":["PMC7991918"],"pubmed_authors":["Gaillard A","Nehme A","Zibara K","Prestoz L","Dakik H","Mantash S","Kobeissy F","Mirzaei P","Mechref Y","Zabet-Moghaddam M"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease.","description":"Advances in large-scale proteomics analysis have been very useful in understanding pathogenesis of diseases and elaborating therapeutic strategies. Proteomics has been employed to study Parkinson disease (PD); however, sparse studies reported proteome investigation after cell therapy approaches. In this study, we used liquid chromatography-tandem mass spectrometry and systems biology to identify differentially expressed proteins in a translational mouse model of PD after cell therapy. Proteins were extracted from five nigrostriatal-related brain regions of mice previously lesioned with 6-hydroxydopamine in the substantia nigra. Protein expression was compared in non-grafted brain to 1 and 7 days after intranigral grafting of E12.5 embryonic ventral mesencephalon (VM). We found a total of 2","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-04-07T21:23:25.178Z","creation":"2022-02-09T08:54:40.175Z"},"accession":"S-EPMC7991918","cross_references":{"pubmed":["33776636"],"doi":["10.3389/fnins.2021.621121"]}}