{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hernansanz-Agustin P"],"funding":["Swiss National Science Foundation","NHLBI NIH HHS","NINDS NIH HHS"],"pagination":["287-291"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7992277"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["586(7828)"],"pubmed_abstract":["All metazoans depend on the consumption of O<sub>2</sub> by the mitochondrial oxidative phosphorylation system (OXPHOS) to produce energy. In addition, the OXPHOS uses O<sub>2</sub> to produce reactive oxygen species that can drive cell adaptations<sup>1-4</sup>, a phenomenon that occurs in hypoxia<sup>4-8</sup> and whose precise mechanism remains unknown. Ca<sup>2+</sup> is the best known ion that acts as a second messenger<sup>9</sup>, yet the role ascribed to Na<sup>+</sup> is to serve as a mere mediator of membrane potential<sup>10</sup>. Here we show that Na<sup>+</sup> acts as a second messenger that regulates OXPHOS function and the production of reactive oxygen species by modulating the fluidity of the inner mitochondrial membrane. A conformational shift in mitochondrial complex I "],"journal":["Nature"],"pubmed_title":["Na<sup>+</sup> controls hypoxic signalling by the mitochondrial respiratory chain."],"pmcid":["PMC7992277"],"funding_grant_id":["R01 HL123966","124970","R01 HL142271","310030","R01 HL136954","RF1 NS121379"],"pubmed_authors":["Cortes A","Martinez-Ruiz A","Cogolludo A","Enriquez JA","Parada E","Lopez MG","Egea J","Acin-Perez R","Martinez-Del-Pozo A","Izquierdo-Alvarez A","Navarro E","Villa-Pina T","Cabrera-Garcia JD","Lopez-Montero I","Carregal-Romero S","Rodriguez-Aguilera JC","Choya-Foces C","Elrod JW","Tello D","Jadiya P","Lechuga-Vieco AV","Ruiz-Cabello J","Bogdanova A","Hernansanz-Agustin P","Moreno L","Palomino-Antolin A","Oliva T","Navas P","Ramos E"],"additional_accession":[]},"is_claimable":false,"name":"Na<sup>+</sup> controls hypoxic signalling by the mitochondrial respiratory chain.","description":"All metazoans depend on the consumption of O<sub>2</sub> by the mitochondrial oxidative phosphorylation system (OXPHOS) to produce energy. In addition, the OXPHOS uses O<sub>2</sub> to produce reactive oxygen species that can drive cell adaptations<sup>1-4</sup>, a phenomenon that occurs in hypoxia<sup>4-8</sup> and whose precise mechanism remains unknown. Ca<sup>2+</sup> is the best known ion that acts as a second messenger<sup>9</sup>, yet the role ascribed to Na<sup>+</sup> is to serve as a mere mediator of membrane potential<sup>10</sup>. Here we show that Na<sup>+</sup> acts as a second messenger that regulates OXPHOS function and the production of reactive oxygen species by modulating the fluidity of the inner mitochondrial membrane. A conformational shift in mitochondrial complex I ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-05-02T11:26:54.066Z","creation":"2025-04-05T17:16:03.366Z"},"accession":"S-EPMC7992277","cross_references":{"pubmed":["32728214"],"doi":["10.1038/s41586-020-2551-y"]}}