{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tsamou M"],"funding":["Karen Vrijens is postdoctoral fellow of the FWO","European Research Council","Flemish Research Council"],"pagination":["373-388"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7993149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(4)"],"pubmed_abstract":["There is an increasing interest in microRNAs (miRNAs) as they are of utmost importance in gene regulation at the posttranscriptional level. Sex-related susceptibility for non-communicable diseases later in life could originate in early life. Until now, no data on sex-specific miRNA expression are available for the placenta. Therefore, we investigated the difference by sex of newborn's miRNA expression in human placental tissue. Within the ENVIR<i>ON</i>AGE birth cohort, miRNA and mRNA expression profiling was performed in 60 placentae (50% boys) using Agilent (8 × 60 K) microarrays. The distribution of chromosome locations was studied and pathway analysis of the identified sex-specific miRNAs in the placenta was carried out. Of the total 2558 miRNAs on the array, 597 miRNAs were expressed "],"journal":["Epigenetics"],"pubmed_title":["Genome-wide microRNA expression analysis in human placenta reveals sex-specific patterns: an ENVIR<i>ON</i>AGE birth cohort study."],"pmcid":["PMC7993149"],"funding_grant_id":["ERC-2012-StG 310898","310898","FWO G073315N","12D7718N"],"pubmed_authors":["Madhloum N","de Kok TM","Winckelmans E","Wang C","Tsamou M","Nawrot TS","Neven KY","Vrijens K"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide microRNA expression analysis in human placenta reveals sex-specific patterns: an ENVIR<i>ON</i>AGE birth cohort study.","description":"There is an increasing interest in microRNAs (miRNAs) as they are of utmost importance in gene regulation at the posttranscriptional level. Sex-related susceptibility for non-communicable diseases later in life could originate in early life. Until now, no data on sex-specific miRNA expression are available for the placenta. Therefore, we investigated the difference by sex of newborn's miRNA expression in human placental tissue. Within the ENVIR<i>ON</i>AGE birth cohort, miRNA and mRNA expression profiling was performed in 60 placentae (50% boys) using Agilent (8 × 60 K) microarrays. The distribution of chromosome locations was studied and pathway analysis of the identified sex-specific miRNAs in the placenta was carried out. Of the total 2558 miRNAs on the array, 597 miRNAs were expressed ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-05-09T07:56:06.259Z","creation":"2022-02-09T17:35:31.933Z"},"accession":"S-EPMC7993149","cross_references":{"pubmed":["32892695"],"doi":["10.1080/15592294.2020.1803467"]}}