{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weiss SL"],"funding":["NICHD NIH HHS","NIMH NIH HHS","NINDS NIH HHS","NIH HHS","NIGMS NIH HHS"],"pagination":["e0360"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7994045"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(3)"],"pubmed_abstract":["<h4>Objectives</h4>The intestinal microbiome can modulate immune function through production of microbial-derived short-chain fatty acids. We explored whether intestinal dysbiosis in children with sepsis leads to changes in microbial-derived short-chain fatty acids in plasma and stool that are associated with immunometabolic dysfunction in peripheral blood mononuclear cells.<h4>Design</h4>Prospective observational pilot study.<h4>Setting</h4>Single academic PICU.<h4>Patients</h4>Forty-three children with sepsis/septic shock and 44 healthy controls.<h4>Measurements and main results</h4>Stool and plasma samples were serially collected for sepsis patients; stool was collected once for controls. The intestinal microbiome was assessed using 16S ribosomal RNA sequencing and alpha- and beta-diver"],"journal":["Critical care explorations"],"pubmed_title":["Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function."],"pmcid":["PMC7994045"],"funding_grant_id":["R01 MH108592","K23 GM110496","K12 HD047349","R01 OD010944","R01 NS021328"],"pubmed_authors":["Wu GD","Mattei LM","Bushman FD","Zhang D","McGowan FX","Balamuth F","Collman RG","Bittinger K","Wallace DC","Friedman ES","Graham K","Weiss SL","Baldassano RN","Bush J","Lee JJ"],"additional_accession":[]},"is_claimable":false,"name":"Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function.","description":"<h4>Objectives</h4>The intestinal microbiome can modulate immune function through production of microbial-derived short-chain fatty acids. We explored whether intestinal dysbiosis in children with sepsis leads to changes in microbial-derived short-chain fatty acids in plasma and stool that are associated with immunometabolic dysfunction in peripheral blood mononuclear cells.<h4>Design</h4>Prospective observational pilot study.<h4>Setting</h4>Single academic PICU.<h4>Patients</h4>Forty-three children with sepsis/septic shock and 44 healthy controls.<h4>Measurements and main results</h4>Stool and plasma samples were serially collected for sepsis patients; stool was collected once for controls. The intestinal microbiome was assessed using 16S ribosomal RNA sequencing and alpha- and beta-diver","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-03-18T13:43:48.429Z","creation":"2025-04-04T11:43:48.101Z"},"accession":"S-EPMC7994045","cross_references":{"pubmed":["33786436"],"doi":["10.1097/CCE.0000000000000360"]}}