biostudies-literature00510Shi QBeijing Ronghe Medical Development FoundationState Key Laboratory of Analytical Chemistry for Life Sciences300060521997661https://www.ebi.ac.uk/biostudies/studies/S-EPMC7995454biostudies-literatureUnknown49(3)<h4>Objective</h4>The objective was to derive and validate a practical scoring system for preoperative diagnosis of Xp11.2 translocation renal cell carcinoma (RCC) in adults.<h4>Methods</h4>Epidemiology, symptomatology, and imaging methods were correlated between patients with common RCC and those with Xp11.2 translocation RCC using a derivation study (N = 6352) and a validation study (N = 127). Univariate analysis of risk factors was performed to derive a scoring system to predict the occurrence of Xp11.2 translocation RCC in adults. The Hosmer-Lemeshow goodness-of-fit test and receiver operating characteristic (ROC) curve were used to validate the scoring system.<h4>Results</h4>Based on odd ratios, three low-risk factors (sex, gross haematuria, and intratumoural calcification) and three high-risk factors (age, unenhanced computed tomography density, and enhancement pattern) were given weighted scores of 1 and 2, respectively. Patients who scored 3 to 5 points underwent an additional magnetic resonance imaging examination. The final scoring system had a sensitivity of 81.0% and a specificity of 98.0%.<h4>Conclusion</h4>We established a practical scoring system for the preoperative diagnosis of Xp11.2 translocation RCC in adults, which can be optimised through further clinical findings in the future.The Journal of international medical researchA new risk-scoring system to predict Xp11.2 translocation renal cell carcinoma in adults.PMC79954545431ZZXM2004Xu LZhang GLi XZhu YLi DLiu NGuo HShi QQu FGan W51falseA new risk-scoring system to predict Xp11.2 translocation renal cell carcinoma in adults.<h4>Objective</h4>The objective was to derive and validate a practical scoring system for preoperative diagnosis of Xp11.2 translocation renal cell carcinoma (RCC) in adults.<h4>Methods</h4>Epidemiology, symptomatology, and imaging methods were correlated between patients with common RCC and those with Xp11.2 translocation RCC using a derivation study (N = 6352) and a validation study (N = 127). Univariate analysis of risk factors was performed to derive a scoring system to predict the occurrence of Xp11.2 translocation RCC in adults. The Hosmer-Lemeshow goodness-of-fit test and receiver operating characteristic (ROC) curve were used to validate the scoring system.<h4>Results</h4>Based on odd ratios, three low-risk factors (sex, gross haematuria, and intratumoural calcification) and three high-risk factors (age, unenhanced computed tomography density, and enhancement pattern) were given weighted scores of 1 and 2, respectively. Patients who scored 3 to 5 points underwent an additional magnetic resonance imaging examination. The final scoring system had a sensitivity of 81.0% and a specificity of 98.0%.<h4>Conclusion</h4>We established a practical scoring system for the preoperative diagnosis of Xp11.2 translocation RCC in adults, which can be optimised through further clinical findings in the future.2021-01-01T00:00:00Z2021 Mar2024-02-15T15:09:47.194Z2022-02-09T12:48:08.897ZS-EPMC79954543375245310.1177/0300060521997661