{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":47,"searchCount":0},"additional":{"submitter":["Borsari C"],"funding":["Associazione Italiana per la Ricerca sul Cancro"],"pagination":["1908-1928"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7997565"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(5)"],"pubmed_abstract":["After the first seed concept introduced in the 18th century, different disciplines have attributed different names to dual-functional molecules depending on their application, including bioconjugates, bifunctional compounds, multitargeting molecules, chimeras, hybrids, engineered compounds. However, these engineered constructs share a general structure: a first component that targets a specific cell and a second component that exerts the pharmacological activity. A stable or cleavable linker connects the two modules of a chimera. Herein, we discuss the recent advances in the rapidly expanding field of chimeric molecules leveraging chemical biology concepts. This Perspective is focused on bifunctional compounds in which one component is a lead compound or a drug. In detail, we discuss chemical features of chimeric molecules and their use for targeted delivery and for target engagement studies."],"journal":["Journal of medicinal chemistry"],"pubmed_title":["Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology."],"pmcid":["PMC7997565"],"funding_grant_id":["AIRC IG16977"],"pubmed_authors":["Costi MP","Tait A","Trader DJ","Borsari C"],"view_count":["47"],"additional_accession":[]},"is_claimable":false,"name":"Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology.","description":"After the first seed concept introduced in the 18th century, different disciplines have attributed different names to dual-functional molecules depending on their application, including bioconjugates, bifunctional compounds, multitargeting molecules, chimeras, hybrids, engineered compounds. However, these engineered constructs share a general structure: a first component that targets a specific cell and a second component that exerts the pharmacological activity. A stable or cleavable linker connects the two modules of a chimera. Herein, we discuss the recent advances in the rapidly expanding field of chimeric molecules leveraging chemical biology concepts. This Perspective is focused on bifunctional compounds in which one component is a lead compound or a drug. In detail, we discuss chemical features of chimeric molecules and their use for targeted delivery and for target engagement studies.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2024-11-20T17:50:45.492Z","creation":"2022-02-09T10:18:04.825Z"},"accession":"S-EPMC7997565","cross_references":{"pubmed":["32023055"],"doi":["10.1021/acs.jmedchem.9b01456"]}}