{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(3)"],"submitter":["Dupuis C"],"funding":["Pfizer","University of Grenoble 1/Albert Michallon University Hospital","Gilead Sciences","Merck"],"pubmed_abstract":["<h4>Background</h4>We aimed to assess the prognostic value of repeated measurements of serum (1-3)-β-D-glucan (BDG), mannan-antigen (mannan-Ag), and antimannan antibodies (antimannan-Ab) for the occurrence of invasive candidiasis (IC) in a high-risk nonimmunocompromised population.<h4>Methods</h4>This was a preplanned ancillary analysis of the EMPIRICUS Randomized Clinical Trial, including nonimmunocompromised critically ill patients with intensive care unit-acquired sepsis, multiple <i>Candida</i> colonization, and multiple organ failure who were exposed to broad-spectrum antibacterial agents. BDG (>80 and >250 pg/mL), mannan-Ag (>125 pg/mL), and antimannan-Ab (>10 AU) were collected repeatedly. We used cause-specific hazard models. Biomarkers were assessed at baseline in the whole cohort (cohort 1). Baseline covariates and/or repeated measurements and/or increased biomarkers were then studied in the subgroup of patients who were still alive at day 3 and free of IC (cohort 2).<h4>Results</h4>Two hundred thirty-four patients were included, and 215 were still alive and free of IC at day 3. IC developed in 27 patients (11.5%), and day 28 mortality was 29.1%. Finally, BDG >80 pg/mL at inclusion was associated with an increased risk of IC (CSHR[IC], 4.67; 95% CI, 1.61-13.5) but not death (CSHR[death], 1.20; 95% CI, 0.71-2.02).<h4>Conclusions</h4>Among high-risk patients, a first measurement of BDG >80 pg/mL was strongly associated with the occurrence of IC. Neither a cutoff of 250 pg/mL nor repeated measurements of fungal biomarkers seemed to be useful to predict the occurrence of IC. The cumulative risk of IC in the placebo group if BDG >80 pg/mL was 25.39%, which calls into question the efficacy of empirical therapy in this subgroup."],"journal":["Open forum infectious diseases"],"pagination":["ofab080"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8002176"],"repository":["biostudies-literature"],"pubmed_title":["Performance of Repeated Measures of (1-3)-β-D-Glucan, Mannan Antigen, and Antimannan Antibodies for the Diagnosis of Invasive Candidiasis in ICU Patients: A Preplanned Ancillary Analysis of the EMPIRICUS Randomized Clinical Trial."],"pmcid":["PMC8002176"],"pubmed_authors":["Ninet S","Prothet J","Foucrier A","Chochillon C","Mourvillier B","Castet A","Bienvenu AL","Pivot C","Faure MJ","Fekkar A","Breuker C","Pichon M","Delabranche X","Timsit JF","El Haouari H","Darmon M","Bru V","Paugam-Burtz CC","Ciroldi M","Klouche K","Chemam S","Martinet O","Fritzsch J","Neagu-Anca R","Maubon D","Arnaud P","Amigues L","Brunee F","Allaouchiche B","Hernu R","Chambrin IM","Bourgeois N","Hammi K","Theodose I","Mordini J","Mira JP","Fournier J","Benveniste E","Estevez L","Faure CJ","Ruckly S","Garrouste-Orgeas M","Mrozek N","Accoberry I","Charbonnier F","Candolfi E","Charles PE","Legrand M","Senghor Y","Gerard C","Zahar JR","Azoulay E","Diconne E","Argaud L","Empiricus Study Group","Rimmele T","Cornet M","Jung B","Meur P","Cavelot S","Papy E","Peccoux SC","Palette C","Schir E","Belafia F","Serveaux M","Lautrette A","Dubien C","Abazid M","Maziers N","Warchol M","Trouillet JL","Picot S","Gruson D","Simon M","Calvet L","Le Bihan C","Machado S","Laurent V","Grenouillet F","Dupuis C","Chastre J","Prades A","Schnell D","Essert M","de La Salle S","Navellou JC","Bruyere R","Ghezzoul B","Bedos JP","Pons D","Dalle F","Beyerle F","Lemiale V","Meziani F","Coisel Y","Wolff M","Floch T","Jaber S","Devaux T","Kitzis MD","Bouadma L","Cour M","Conseil M","Zarski JP","Millaret A","Zeni F","Tacco F","Schlemmer B","Vesin A","Boisrame-Helms J","Raclot P","Sonneville R","Misset B","Roos S","Hamidfar-Roy R","Rodriguez A","Toubas D","Ber CE","Schwebel C","Guillaume C","Dupre K","Cousson J","Lacave G","Raberin H","Clauss AH","Cherifi M","Pattyn A","Souweine B","Hamet M","Coudrot M","Letrou S","Kodja LB","Bayarassou S","Styfalova L","Fagnoni P","Larrey D","Gerbouin O"],"additional_accession":[]},"is_claimable":false,"name":"Performance of Repeated Measures of (1-3)-β-D-Glucan, Mannan Antigen, and Antimannan Antibodies for the Diagnosis of Invasive Candidiasis in ICU Patients: A Preplanned Ancillary Analysis of the EMPIRICUS Randomized Clinical Trial.","description":"<h4>Background</h4>We aimed to assess the prognostic value of repeated measurements of serum (1-3)-β-D-glucan (BDG), mannan-antigen (mannan-Ag), and antimannan antibodies (antimannan-Ab) for the occurrence of invasive candidiasis (IC) in a high-risk nonimmunocompromised population.<h4>Methods</h4>This was a preplanned ancillary analysis of the EMPIRICUS Randomized Clinical Trial, including nonimmunocompromised critically ill patients with intensive care unit-acquired sepsis, multiple <i>Candida</i> colonization, and multiple organ failure who were exposed to broad-spectrum antibacterial agents. BDG (>80 and >250 pg/mL), mannan-Ag (>125 pg/mL), and antimannan-Ab (>10 AU) were collected repeatedly. We used cause-specific hazard models. Biomarkers were assessed at baseline in the whole cohort (cohort 1). Baseline covariates and/or repeated measurements and/or increased biomarkers were then studied in the subgroup of patients who were still alive at day 3 and free of IC (cohort 2).<h4>Results</h4>Two hundred thirty-four patients were included, and 215 were still alive and free of IC at day 3. IC developed in 27 patients (11.5%), and day 28 mortality was 29.1%. Finally, BDG >80 pg/mL at inclusion was associated with an increased risk of IC (CSHR[IC], 4.67; 95% CI, 1.61-13.5) but not death (CSHR[death], 1.20; 95% CI, 0.71-2.02).<h4>Conclusions</h4>Among high-risk patients, a first measurement of BDG >80 pg/mL was strongly associated with the occurrence of IC. Neither a cutoff of 250 pg/mL nor repeated measurements of fungal biomarkers seemed to be useful to predict the occurrence of IC. The cumulative risk of IC in the placebo group if BDG >80 pg/mL was 25.39%, which calls into question the efficacy of empirical therapy in this subgroup.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2024-10-15T22:21:58.341Z","creation":"2022-02-09T14:13:32.484Z"},"accession":"S-EPMC8002176","cross_references":{"pubmed":["33816643"],"doi":["10.1093/ofid/ofab080"]}}