biostudies-literatureLee KLWan Fang Hospital, Taipei Medical University427https://www.ebi.ac.uk/biostudies/studies/S-EPMC8002550biostudies-literatureUnknown12(3)Non-small cell lung cancer (NSCLC) is a typical inflammation-associated cancer, and lung adenocarcinoma (LUAD) is the most common histopathological subtype. Epidermal growth factor receptor (EGFR) mutations are the most common driver mutations of LUAD, and they have been identified as important therapeutic targets by EGFR tyrosine kinase inhibitors. Interleukin (IL)-17A secreted by T-helper 17 lymphocytes is a proinflammatory cytokine that plays an important role in cancer pathogenesis. The present study was designed to investigate the possible associations among IL-17A genetic polymorphisms, EGFR mutation status, and the clinicopathologic development of LUAD in a Taiwanese population. Our study population consisted of 277 LUAD patients harboring the wild-type (WT) EGFR or a mutant (MT) EGGenesPotential Impacts of <i>Interleukin-17A</i> Promoter Polymorphisms on the <i>EGFR</i> Mutation Status and Progression of Non-Small Cell Lung Cancer in Taiwan.PMC8002550110-swf-06Tsao TCWang YCYang YCChang LCLiu TCLee KLShih PCChien MHLai TCYang SFWen YCfalsePotential Impacts of <i>Interleukin-17A</i> Promoter Polymorphisms on the <i>EGFR</i> Mutation Status and Progression of Non-Small Cell Lung Cancer in Taiwan.Non-small cell lung cancer (NSCLC) is a typical inflammation-associated cancer, and lung adenocarcinoma (LUAD) is the most common histopathological subtype. Epidermal growth factor receptor (EGFR) mutations are the most common driver mutations of LUAD, and they have been identified as important therapeutic targets by EGFR tyrosine kinase inhibitors. Interleukin (IL)-17A secreted by T-helper 17 lymphocytes is a proinflammatory cytokine that plays an important role in cancer pathogenesis. The present study was designed to investigate the possible associations among IL-17A genetic polymorphisms, EGFR mutation status, and the clinicopathologic development of LUAD in a Taiwanese population. Our study population consisted of 277 LUAD patients harboring the wild-type (WT) EGFR or a mutant (MT) EG2021-01-01T00:00:00Z2021 Mar2026-05-03T08:58:28.533Z2022-02-09T14:48:36.926ZS-EPMC80025503380273710.3390/genes12030427