{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(6)"],"submitter":["Perez Diaz N"],"pubmed_abstract":["Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role of PPARβ/δ in disease, having both anti- and pro-effects on inflammation. After ligand activation, PPARβ/δ regulates genes by two different mechanisms; induction and transrepression, the effects of which are difficult to differentiate directly. We studied the PPARβ/δ-regulation of lipopolysaccharide (LPS) induced inflammation (indicated by release of nitrite and IL-6) of rat pulmonary artery, using different combinations of agonists (GW0742 or L-165402) and antagonists (GSK3787 or GSK0660). LPS induced release of NO and IL-6 is not significantly reduced by incubation with"],"journal":["International journal of molecular sciences"],"pagination":["3158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8003823"],"repository":["biostudies-literature"],"pubmed_title":["Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery."],"pmcid":["PMC8003823"],"pubmed_authors":["Perez Diaz N","Lione LA","Hutter V","Mackenzie LS"],"additional_accession":[]},"is_claimable":false,"name":"Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery.","description":"Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role of PPARβ/δ in disease, having both anti- and pro-effects on inflammation. After ligand activation, PPARβ/δ regulates genes by two different mechanisms; induction and transrepression, the effects of which are difficult to differentiate directly. We studied the PPARβ/δ-regulation of lipopolysaccharide (LPS) induced inflammation (indicated by release of nitrite and IL-6) of rat pulmonary artery, using different combinations of agonists (GW0742 or L-165402) and antagonists (GSK3787 or GSK0660). LPS induced release of NO and IL-6 is not significantly reduced by incubation with","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-06-01T01:35:46.243Z","creation":"2025-06-01T01:35:46.243Z"},"accession":"S-EPMC8003823","cross_references":{"pubmed":["33808880"],"doi":["10.3390/ijms22063158"]}}