{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kotkowski E"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","NICHD NIH HHS","NIA NIH HHS","NIMH NIH HHS","National Institute of Mental Health","National Institutes of Health","NIH HHS","NIGMS NIH HHS"],"pagination":["295-299"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8005432"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(2)"],"pubmed_abstract":["The posterior cerebellum is the most significantly compromised brain structure in individuals with metabolic syndrome (MetS) (Hum Brain Mapp 40(12):3575-3588, 2019). In light of this, we hypothesized that cognitive decline reported in patients with MetS is likely related to posterior cerebellar atrophy. In this study, we performed a post hoc analyses using T1-weighted magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) in the form of voxel-wise tract-based spatial statistics (TBSS), biometric, and psychometric data from young participants with (n = 52, aged 18-35 years) and without MetS (n = 52, aged 18-35 years). To test the predictive value of components of the Schmahmann syndrome scale (SSS), also known as the cerebellar cognitive affective syndrome scale, we used structura"],"journal":["Cerebellum (London, England)"],"pubmed_title":["Using the Schmahmann Syndrome Scale to Assess Cognitive Impairment in Young Adults with Metabolic Syndrome: a Hypothesis-Generating Report."],"pmcid":["PMC8005432"],"funding_grant_id":["R01MH074457-11S1","T32GM113898","R01 MH074457","R01 AG058464","P50 HD105351","TL1 TR002647","TL1TR002647-01","T32 GM113896","R56 MH074457"],"pubmed_authors":["Kotkowski E","Fox PT","DeFronzo RA","Blevins CJ","Schmahmann JD","Franklin CG","Blangero J","Glahn DC","Woolsey MD","Duggirala R","Price LR"],"additional_accession":[]},"is_claimable":false,"name":"Using the Schmahmann Syndrome Scale to Assess Cognitive Impairment in Young Adults with Metabolic Syndrome: a Hypothesis-Generating Report.","description":"The posterior cerebellum is the most significantly compromised brain structure in individuals with metabolic syndrome (MetS) (Hum Brain Mapp 40(12):3575-3588, 2019). In light of this, we hypothesized that cognitive decline reported in patients with MetS is likely related to posterior cerebellar atrophy. In this study, we performed a post hoc analyses using T1-weighted magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) in the form of voxel-wise tract-based spatial statistics (TBSS), biometric, and psychometric data from young participants with (n = 52, aged 18-35 years) and without MetS (n = 52, aged 18-35 years). To test the predictive value of components of the Schmahmann syndrome scale (SSS), also known as the cerebellar cognitive affective syndrome scale, we used structura","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-04T02:37:46.681Z","creation":"2024-11-15T21:01:36.016Z"},"accession":"S-EPMC8005432","cross_references":{"pubmed":["33159660"],"doi":["10.1007/s12311-020-01212-9"]}}