biostudies-literatureKotkowski ENational Center for Advancing Translational SciencesNCATS NIH HHSNICHD NIH HHSNIA NIH HHSNIMH NIH HHSNational Institute of Mental HealthNational Institutes of HealthNIH HHSNIGMS NIH HHS295-299https://www.ebi.ac.uk/biostudies/studies/S-EPMC8005432biostudies-literatureUnknown20(2)The posterior cerebellum is the most significantly compromised brain structure in individuals with metabolic syndrome (MetS) (Hum Brain Mapp 40(12):3575-3588, 2019). In light of this, we hypothesized that cognitive decline reported in patients with MetS is likely related to posterior cerebellar atrophy. In this study, we performed a post hoc analyses using T1-weighted magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) in the form of voxel-wise tract-based spatial statistics (TBSS), biometric, and psychometric data from young participants with (n = 52, aged 18-35 years) and without MetS (n = 52, aged 18-35 years). To test the predictive value of components of the Schmahmann syndrome scale (SSS), also known as the cerebellar cognitive affective syndrome scale, we used structuraCerebellum (London, England)Using the Schmahmann Syndrome Scale to Assess Cognitive Impairment in Young Adults with Metabolic Syndrome: a Hypothesis-Generating Report.PMC8005432R01MH074457-11S1T32GM113898R01 MH074457R01 AG058464P50 HD105351TL1 TR002647TL1TR002647-01T32 GM113896R56 MH074457Kotkowski EFox PTDeFronzo RABlevins CJSchmahmann JDFranklin CGBlangero JGlahn DCWoolsey MDDuggirala RPrice LRfalseUsing the Schmahmann Syndrome Scale to Assess Cognitive Impairment in Young Adults with Metabolic Syndrome: a Hypothesis-Generating Report.The posterior cerebellum is the most significantly compromised brain structure in individuals with metabolic syndrome (MetS) (Hum Brain Mapp 40(12):3575-3588, 2019). In light of this, we hypothesized that cognitive decline reported in patients with MetS is likely related to posterior cerebellar atrophy. In this study, we performed a post hoc analyses using T1-weighted magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) in the form of voxel-wise tract-based spatial statistics (TBSS), biometric, and psychometric data from young participants with (n = 52, aged 18-35 years) and without MetS (n = 52, aged 18-35 years). To test the predictive value of components of the Schmahmann syndrome scale (SSS), also known as the cerebellar cognitive affective syndrome scale, we used structura2021-01-01T00:00:00Z2021 Apr2025-04-04T02:37:46.681Z2024-11-15T21:01:36.016ZS-EPMC80054323315966010.1007/s12311-020-01212-9