{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ren CZ"],"funding":["Innovation Project of Guangxi Graduate Education","National Natural Science Foundation of China"],"pagination":["e20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8007442"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(2)"],"pubmed_abstract":["<h4>Background</h4><i>Pseudorabies</i> virus (PRV) infection leads to high mortality in swine. Despite extensive efforts, effective treatments against PRV infection are limited. Furthermore, the inflammatory response induced by PRV strain GXLB-2013 is unclear.<h4>Objectives</h4>Our study aimed to investigate the inflammatory response induced by PRV strain GXLB-2013, establish an inflammation model to elucidate the pathogenesis of PRV infection further, and develop effective drugs against PRV infection.<h4>Methods</h4>Kunming mice were infected intramuscularly with medium, LPS, and different doses of PRV-GXLB-2013. Viral spread and histopathological damage to brain, spleen, and lung were determined at 7 days post-infection (dpi). Immune organ indices, levels of reactive oxygen species (ROS)"],"journal":["Journal of veterinary science"],"pubmed_title":["Establishment of inflammatory model induced by <i>Pseudorabies</i> virus infection in mice."],"pmcid":["PMC8007442"],"funding_grant_id":["YCBZ2020004","32072907"],"pubmed_authors":["Wei YY","Ren CZ","Zhang JW","Hu TJ","Yu ML","Hu WY"],"additional_accession":[]},"is_claimable":false,"name":"Establishment of inflammatory model induced by <i>Pseudorabies</i> virus infection in mice.","description":"<h4>Background</h4><i>Pseudorabies</i> virus (PRV) infection leads to high mortality in swine. Despite extensive efforts, effective treatments against PRV infection are limited. Furthermore, the inflammatory response induced by PRV strain GXLB-2013 is unclear.<h4>Objectives</h4>Our study aimed to investigate the inflammatory response induced by PRV strain GXLB-2013, establish an inflammation model to elucidate the pathogenesis of PRV infection further, and develop effective drugs against PRV infection.<h4>Methods</h4>Kunming mice were infected intramuscularly with medium, LPS, and different doses of PRV-GXLB-2013. Viral spread and histopathological damage to brain, spleen, and lung were determined at 7 days post-infection (dpi). Immune organ indices, levels of reactive oxygen species (ROS)","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T08:26:37.737Z","creation":"2022-02-09T12:52:54.827Z"},"accession":"S-EPMC8007442","cross_references":{"pubmed":["33774936"],"doi":["10.4142/jvs.2021.22.e20"]}}