biostudies-literatureRen CZInnovation Project of Guangxi Graduate EducationNational Natural Science Foundation of Chinae20https://www.ebi.ac.uk/biostudies/studies/S-EPMC8007442biostudies-literatureUnknown22(2)<h4>Background</h4><i>Pseudorabies</i> virus (PRV) infection leads to high mortality in swine. Despite extensive efforts, effective treatments against PRV infection are limited. Furthermore, the inflammatory response induced by PRV strain GXLB-2013 is unclear.<h4>Objectives</h4>Our study aimed to investigate the inflammatory response induced by PRV strain GXLB-2013, establish an inflammation model to elucidate the pathogenesis of PRV infection further, and develop effective drugs against PRV infection.<h4>Methods</h4>Kunming mice were infected intramuscularly with medium, LPS, and different doses of PRV-GXLB-2013. Viral spread and histopathological damage to brain, spleen, and lung were determined at 7 days post-infection (dpi). Immune organ indices, levels of reactive oxygen species (ROS)Journal of veterinary scienceEstablishment of inflammatory model induced by <i>Pseudorabies</i> virus infection in mice.PMC8007442YCBZ202000432072907Wei YYRen CZZhang JWHu TJYu MLHu WYfalseEstablishment of inflammatory model induced by <i>Pseudorabies</i> virus infection in mice.<h4>Background</h4><i>Pseudorabies</i> virus (PRV) infection leads to high mortality in swine. Despite extensive efforts, effective treatments against PRV infection are limited. Furthermore, the inflammatory response induced by PRV strain GXLB-2013 is unclear.<h4>Objectives</h4>Our study aimed to investigate the inflammatory response induced by PRV strain GXLB-2013, establish an inflammation model to elucidate the pathogenesis of PRV infection further, and develop effective drugs against PRV infection.<h4>Methods</h4>Kunming mice were infected intramuscularly with medium, LPS, and different doses of PRV-GXLB-2013. Viral spread and histopathological damage to brain, spleen, and lung were determined at 7 days post-infection (dpi). Immune organ indices, levels of reactive oxygen species (ROS)2021-01-01T00:00:00Z2021 Mar2025-04-04T08:26:37.737Z2022-02-09T12:52:54.827ZS-EPMC80074423377493610.4142/jvs.2021.22.e20